Aging and cancer hallmarks as therapeutic targets

Announcing a new publication for Acta Materia Medica journal.  The prevalence of age-related diseases has been progressively increasing worldwide. The pathogenesis of these disorders, including cancer, is closely associated with an age-dependent decline in cellular functions. There are multiple layers of crosstalk between aging processes and oncogenesis. Therefore, a better understanding of the interplay between aging and cancer will facilitate the development of novel therapeutic intervention strategies for malignancies at advanced ages. Recent review articles have concisely summarized and updated aging and cancer hallmark features and adequately discussed the interplays at both the cellular and molecular levels. Because aging and cancer share several key mechanisms that define the hallmarks, targeting shared features, such as cellular senescence, may be beneficial for cancer prevention and treatments. Notably, senolysis, an innovative therapeutic intervention for selectively removing senescent cells, holds great promise for developing new therapeutic approaches for cancers and other age-related diseases, such as viral infections and cardiovascular diseases.

The authors of this article briefly summarize the recently updated knowledge on aging and cancer hallmarks, as well as the advances in senolysis for age-related conditions.

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eISSN 2737-7946

Jingchao Wang, Jonathan Wei and Hiroyuki Inuzuka. Aging and cancer hallmarks as therapeutic targets. Acta Materia Medica. 2023. Vol. 2(3):281-284. DOI: 10.15212/AMM-2023-0018