Announcing a new publication for Acta Materia Medica journal. Hydrogen sulfide (H2S) plays crucial roles in antioxidation, anti-inflammation, and cytoprotection. Despite substantial progress in the design and synthesis of activatable H2S donors, methods for high-precision detection and imaging of released H2S in living systems have been lacking. In this study, a biothiol-activated near-infrared (NIR) fluorescent […]
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Cytotoxic compounds from marine actinomycetes: sources, structures and bioactivity
Announcing a new publication for Acta Materia Medica journal. Marine actinomycetes produce a substantial number of natural products with cytotoxic activity. Actinomycete strains have been isolated from sources including fishes, coral, sponges, seaweeds, mangroves and sediments. These cytotoxic compounds can be broadly categorized into four classes: polyketides; non-ribosomal peptides and hybrids; isoprenoids and hybrids; and […]
Structurally diverse polydopamine-based nanomedicines for cancer therapy
Announcing a new publication for Acta Materia Medica journal. Mussel-inspired polydopamine (PDA) has attracted substantial interest in materials synthesis, energy storage, environmental governance, and biomedical science since it was first reported in 2007. PDA, owing to its excellent biocompatibility and photothermal conversion efficiency (η), has been used in photothermal therapy alone and in combination with […]
Recent progress in cancer therapy based on the combination of ferroptosis with photodynamic therapy
Announcing a new publication for Acta Materia Medica journal. Current anticancer treatments have many limitations to achieving high efficacy. Hence, novel strategies that broaden therapeutic prospects must urgently be developed. Ferroptosis is an iron-dependent form of non-apoptotic programmed cell death that is induced by cellular antioxidative system inhibition. Photodynamic therapy (PDT) uses photosensitizers to generate […]
In vitro characterization and cellular uptake profiles of TAMs-targeted lipid calcium carbonate nanoparticles for cancer immunotherapy
Announcing a new publication for Acta Materia Medica journal. Tumor-associated macrophages (TAMs) are key contributors to tumor development, accelerated tumor invasion and metastasis, and induction of immunosuppression. Targeted delivery of immunomodulatory agents to promote polarization of TAMs may alleviate the immunosuppressive tumor microenvironment. Calcium carbonate nanoparticles (CCN), which exhibit excellent biocompatibility, pH sensitivity, and easy […]
Protective effects of ginsenoside CK against oxidative stress-induced neuronal damage, assessed with 1H-NMR-based metabolomics
Announcing a new publication for Acta Materia Medica journal. Oxidative stress is an important pathogenic mechanism in degenerative diseases such as Alzheimer’s disease. Although ginsenoside compound K (CK) is protective against neuronal oxidative damage, the underlying mechanism remains to be understood. In this article, the protective effects of ginsenoside CK against oxidative stress damage induced […]
The direct STAT3 inhibitor 6-ethoxydihydrosanguinarine exhibits anticancer activity in gastric cancer
Announcing a new publication for Acta Materia Medica journal. Signal transducer and activator of transcription 3 (STAT3) plays a key role in promoting tumor malignant progression. Suppression of hyperactivated STAT3 signaling has emerged as a potential therapeutic strategy for many cancer types. In this article, the effect of 6-ethoxydihydrosanguinarine (6-EDS), a secondary transformation product formed […]
Molecular mechanisms of transporter regulation and their impairment in intrahepatic cholestasis
Announcing a new publication for Acta Materia Medica journal. Intrahepatic cholestasis (IC) is a liver disease caused by disorders in bile formation and excretion, owing to structural and functional abnormalities in hepatocytes and/or bile capillaries. IC is commonly caused by hepatitis virus, alcohol consumption, drug-induced liver damage, autoimmune liver disease and heredity. In the absence […]
MDM2-BCL-X L PROTACs enable degradation of BCL-X L and stabilization of p53
Announcing a new publication for Acta Materia Medica journal. Inhibition or degradation of the anti-apoptotic protein BCL-XL is a viable strategy for cancer treatment. Despite the recent development of PROTACs for degradation of BCL-XL, the choice of E3 ligase has been restricted to VHL and CRBN. The authors of this article report the development of MDM2-BCL-XL PROTACs […]
Statistical evaluation of absolute change versus responder analysis in clinical trials
Announcing a new publication for Acta Materia Medica journal. In clinical trials, the primary analysis is often either a test of absolute/relative change in a measured outcome or a corresponding responder analysis. Although each of these tests may be reasonable, determining which test is most suitable for a particular research study remains an open question. […]