Announcing a new publication for Acta Materia Medica journal. G protein-coupled receptor 35 (GPR35) has gained increasing attention as a promising target in treating inflammatory and gastrointestinal tract conditions, cardiovascular diseases, and cancer. Metabolites including kynurenic acid, lysophosphatidic acids, chemokine 17, and 5-hydroxyindole acetic acid have been suggested to be endogenous ligands of GPR35. However, […]
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Drug-like properties of serial phenanthroindolizidine alkaloid compounds: ADMET characteristic prediction and validation
Announcing a new publication for Acta Materia Medica journal. Phenanthroindolizidine alkaloids (PAs) are a series of compounds that have been isolated from traditional herbal medicines and have significant therapeutic potential, such as anti-arthritic, anti-viral, anti-inflammatory, and anti-glioma effects in vitro and in vivo. This study predicts the absorption, distribution, metabolism, excretion, and toxicity (ADMET) characteristics of 44 compounds in […]
Application of PROTACs in target identification and validation
Announcing a new publication for Acta Materia Medica journal. Proteolysis targeting chimeras (PROTACs), as a novel therapeutic drug model, has received widespread attention from academia and the pharmaceutical industry. PROTAC technology has led researchers to focus on developing chemical biology tool properties due to the unique operating mechanism and protein dynamic regulatory properties. In recent […]
New generation estrogen receptor-targeted agents in breast cancer
Announcing a new publication for Acta Materia Medica journal. Endocrine therapy that blocks estrogen receptor signaling has been effective for decades as a primary treatment choice for breast cancer patients expressing the estrogen receptor. However, the issue of drug resistance poses a significant clinical challenge. It is therefore critically important to create new therapeutic agents […]
A comparative analysis of vaccine lists, prices, and candidates, and the national immunization program between China and the United States
Announcing a new publication for Acta Materia Medica journal. Vaccines have an essential role in preventing infectious diseases and reducing the burden of disease. In this article the differences in vaccine lists and prices, and the National Immunization Program (NIP) and vaccine development between China and the United States (US) in conjunction with epidemiologic data […]
G protein-coupled receptor-biased signaling: potential drug discovery to facilitate treatment of metabolic diseases
Announcing a new publication for Acta Materia Medica journal. G protein-coupled receptors (GPCRs) are important, potential drug targets for the treatment of metabolic disorders, such as obesity. GPCRs crosstalk with several transducers, including heterotrimeric G proteins, GPCR kinases (GRKs), and β-arrestins. GPCR-biased agonism has raised the potential of novel drug development to preferentially activate therapeutic […]
Type 1 diabetes mellitus, hyperlipidemia, and inflammatory bowel disease
Announcing a new publication for Acta Materia Medica journal. Previous epidemiologic studies have shown a close association between type 1 diabetes mellitus (T1DM), hyperlipidemia, and inflammatory bowel disease (IBD), but the causal relationship has not been established. The authors of this articles assessed the causal relationships between T1DM and hyperlipidemia with IBD using Mendelian randomization […]
Endocrine toxicity of immune checkpoint inhibitors: a network meta-analysis of the current evidence
Announcing a new publication for Acta Materia Medica journal. Immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment but pose a challenge of immune-related adverse events (irAEs), particularly endocrine toxicity, that can severely compromise patient well-being. Existing research has often been limited in scope and has not provided comprehensive safety profiles across the diverse range of […]
Acta Materia Medica indexed in CAS
We are delighted to announce that Acta Materia Medica is now indexed by CAS. CAS provides accurate and authoritative chemistry content, curated and quality-controlled by hundreds of Ph.D. scientists from around the world. CAS content covers all disclosed chemistry and related science from thousands of journals and 64 patent authorities, as well as reputable Web sources, […]
Advances in microbial decorations and its applications in drug delivery
Announcing a new publication for Acta Materia Medica journal. Microorganisms are mostly distributed on the surface of our skin and intestines and have crucial roles in physiologic and metabolic processes, such as digestion and immunity, which are closely related to diseases. Recently, microorganisms have received great attention and have been applied in various aspects of […]