Announcing a new publication for Acta Materia Medica journal. To determine the protective effects of FM0807 against diabetes-induced renal inflammation and fibrosis and the underlying mechanisms in vivo and in vitro. FM0807 was administered to db/db mice. Glomerular mesangial cells (HBZY-1) were cultured under high glucose conditions with or without FM0807. Gene and protein expression was assessed by […]
Category: News and Events
Pristimerin inhibits thioredoxin reductase in the treatment of non-small cell lung cancer
Announcing a new publication for Acta Materia Medica journal. Elevated cellular oxidative stress is a common marker of cancer cell dysregulation caused by malignant transformation. Thioredoxin reductase (TrxR, encoded by TXNRD) is a crucial enzyme that regulates cellular oxidative stress and the survival of many types of cancer cells. Therefore, targeting TrxR may lead to selective […]
Development and characterization of temperature-sensitive hydrogels embedded with sodium alginate-chitosan microspheres
Announcing a new publication for Acta Materia Medica journal. Ulcerative colitis (UC) is a chronic intestinal disorder characterized by severe intestinal inflammation and superficial mucosal ulcers. Ramulus mori alkaloids (SZ-A) were approved by the National Medical Products Administration of China in 2020 for the treatment of type 2 diabetes mellitus. Later studies confirmed that SZ-A […]
The KIT ligand KITLG promotes portal vein tumor thrombosis by up-regulating COL4A1 through STAT3-SMAD2 signaling in hepatocellular carcinoma
Announcing a new publication for Acta Materia Medica journal. Portal vein tumor thrombosis (PVTT), a severe complication of hepatocellular carcinoma (HCC), markedly influences patient prognosis by fostering a hypercoagulable state. However, its molecular underpinnings remain largely unexplored. This study sheds light on the critical role of the KIT ligand (KITLG) in modulating expression of the […]
Role of natural products in tumor therapy from basic research and clinical perspectives
Announcing a new publication for Acta Materia Medica journal. Cancer is the leading cause of morbidity and mortality worldwide and is an important barrier to lengthening life expectancy in every country. Natural products are receiving increased attention from researchers globally and increasing numbers of natural products are approved for clinical studies involving cancer in recent […]
Acta Materia Medica now indexed by SCOPUS
We are happy to announce this very good news to all authors, editors, reviewers and readers. Acta Materia Medica will be indexed by SCOPUS from May 27th, 2024. The bibliographic database managed by Elsevier covers high-ranking peer-reviewed journals in the technical, medical and social sciences. On this occasion, congratulations to Professor Hongxi Xu and Professor […]
The andrographolide derivative, AND7, and TRAIL combination attenuates acute lymphoblastic leukemia through P53-regulated ROS accumulation
Announcing a new publication for Acta Materia Medica journal. Acute lymphoblastic leukemia (ALL) is a malignant disease of the hematologic system. The current treatment is based on chemotherapeutic drugs, which are becoming less effective due to drug resistance. TNF-related apoptosis-inducing ligand (TRAIL) is an apoptotic protein used to treat cancer that does not affect healthy […]
Glyceraldehyde derivatives inspired by empagliflozin as potential anti-heart failure agents independent of glucose-lowering effects
Announcing a new publication for Acta Materia Medica journal. Sodium-glucose cotransporter 2 inhibitors are a class of glucose-lowering drugs known for robust cardiovascular protective properties. However, the side effects induced by Sodium-glucose cotransporter 2 inhibition limit application in cardiovascular medicine. Prior research showed that thoughtful structural modifications can dissociate the anti-heart failure activity from glucose-lowering […]
Nose-to-brain drug delivery by HS15 micelles for brain targeting of insoluble drug
Announcing a new publication for Acta Materia Medica journal. Agomelatine (AGO) is an antidepressant with limited clinical application due to its low bioavailability caused by poor water solubility, severe hepatic degradation, and poor intracerebral distribution. Nanotechnology-based strategies constitute a powerful tool by utilizing drug solubility and targeted distribution to improve drug bioavailability in the brain […]
Identification of GPR35-associated metabolic characteristics through LC-MS/MS-based metabolomics and lipidomics
Announcing a new publication for Acta Materia Medica journal. G protein-coupled receptor 35 (GPR35) has gained increasing attention as a promising target in treating inflammatory and gastrointestinal tract conditions, cardiovascular diseases, and cancer. Metabolites including kynurenic acid, lysophosphatidic acids, chemokine 17, and 5-hydroxyindole acetic acid have been suggested to be endogenous ligands of GPR35. However, […]