Category: News and Events

Establishment of a protein thermal shift chip (PTSC) for COVID-19 and exploration of the future of protein chips in pharmacology

Announcing a new review article publication for Acta Materia Medica journal. Traditional protein chips are based on solid chips and cannot enable drug and target screening in a label-free manner. The authors of this article propose a protein thermal shift chip (PTSC) based on fluorescence signals, which enables low-cost, high-throughput, label-free screening. The authors developed […]

Silybin has therapeutic efficacy against non-small cell lung cancer through targeting of Skp2

Announcing a new review article publication for Acta Materia Medica journal. Silybin (SB), a natural flavonoid isolated from Silybum marianum, has been used to treat hepatic fibrosis in clinical settings and as a dietary supplement, because of its hepatoprotective potential. Numerous studies have shown that SB also exerts promising anticancer effects; however, the anticancer targets of […]

Factors associated with pharmacists’ knowledge regarding high-alert medications: a convenience sample survey in China

Announcing a new review article publication for Acta Materia Medica journal.  The consequences of medication errors are more severe for high-alert medications than general drugs. Improving pharmacists’ knowledge regarding high-alert medications is important to increase drug safety and maintain patient health. This article reports a study aimed at understanding Chinese hospital pharmacists’ knowledge regarding high-alert […]

Brusatol modulates diverse cancer hallmarks and signaling pathways as a potential cancer therapeutic

Announcing a new review article publication for Acta Materia Medica journal.   Cancer is a consequence of uncontrolled cell proliferation that is associated with cell-cycle disruption. It is a multifactorial disease that depends on the modulation of numerous oncogenic signaling pathways and targets and is a major cause of death worldwide. Because of the development of […]

Structure prediction of the entire proteome of monkeypox variants

Announcing a new review article publication for Acta Materia Medica journal.  Recently, the monkeypox virus has begun to spread in many countries worldwide. The genome sequence of the monkeypox virus variant responsible for the current outbreak has been reported, thus providing an important resource for better understanding the new variant and accelerating vaccine and drug […]

Acta Materia Medica Meets with the Experts Antibacterial and Antitumor Activities of Metal Complexes and their Mechanisms

Acta Materia Medica hosted an online webinar, ‘Antibacterial and Antitumor Activities of Metal Complexes and their Mechanisms’ on Thursday June 9 2022. Presenter: Professor Wei Xia, Sun Yat-sen University, Guangzhou, China Wei Xia received his B.S. degree from Peking University in 2006 and Ph.D. degree from the University of Hong Kong in 2011. From 2011 […]

PROTAC degraders with ligands recruiting MDM2 E3 ubiquitin ligase: an updated perspective

Announcing a new review article publication for Acta Materia Medica journal.  Mouse double minute 2 (MDM2) is an oncogenic E3 ligase that effectively degrades the tumor suppressor p53. In the past two decades, many MDM2 inhibitors that disrupt MDM2-p53 binding have been discovered and developed. Given that MDM2 and p53 form an auto-regulatory loop, in […]

Discovery and characterization of naturally occurring chalcones as potent inhibitors of bile salt hydrolases

Announcing a new review article publication for Acta Materia Medica journal.  Bile salt hydrolases (BSHs) play crucial roles in the deconjugation of conjugated bile acids and therefore are key targets for modulating bile acid metabolism. This authors of this article aimed to identify efficacious BSH inhibitors from a natural compound library and to characterize their […]

Effects of B-carotene on glucose metabolism dysfunction in humans and type 2 diabetic rats

Announcing a new review article publication for Acta Materia Medica journal. Type 2 diabetes mellitus (T2DM) is a common chronic disease that is strongly associated with cardiovascular risk. Long-term high blood glucose levels may induce cardiomyocyte apoptosis, cardiac dysfunction and suppress fetal cardiomyocyte proliferation. Recent epidemiological studies have shown a link between antioxidant carotenoids and […]

Research progress in 3D-printed medicinal tablets

Announcing a new review article publication for Acta Materia Medica journal.  Three-dimensional printing (3DP) is a rapid-prototyping technology that uses a digital model file to construct an object through layer printing. This novel technology is widely used in aerospace, medicine, architecture and industrial applications. However, the pharmaceutical applications of 3DP technology remain in early stages, […]