Category: News and Events

Type 1 diabetes mellitus, hyperlipidemia, and inflammatory bowel disease

Announcing a new publication for Acta Materia Medica journal. Previous epidemiologic studies have shown a close association between type 1 diabetes mellitus (T1DM), hyperlipidemia, and inflammatory bowel disease (IBD), but the causal relationship has not been established. The authors of this articles assessed the causal relationships between T1DM and hyperlipidemia with IBD using Mendelian randomization […]

Endocrine toxicity of immune checkpoint inhibitors: a network meta-analysis of the current evidence

Announcing a new publication for Acta Materia Medica journal. Immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment but pose a challenge of immune-related adverse events (irAEs), particularly endocrine toxicity, that can severely compromise patient well-being. Existing research has often been limited in scope and has not provided comprehensive safety profiles across the diverse range of […]

Acta Materia Medica indexed in CAS

We are delighted to announce that Acta Materia Medica is now indexed by CAS. CAS provides accurate and authoritative chemistry content, curated and quality-controlled by hundreds of Ph.D. scientists from around the world.  CAS content covers all disclosed chemistry and related science from thousands of journals and 64 patent authorities, as well as reputable Web sources, […]

Advances in microbial decorations and its applications in drug delivery

Announcing a new publication for Acta Materia Medica journal.  Microorganisms are mostly distributed on the surface of our skin and intestines and have crucial roles in physiologic and metabolic processes, such as digestion and immunity, which are closely related to diseases. Recently, microorganisms have received great attention and have been applied in various aspects of […]

Single-cell RNA sequencing reveals the effects of hederasaponin C in the treatment of diabetic nephropathy

Announcing a new publication for Acta Materia Medica journal. There is great demand for the development of novel efficient therapeutic strategies or preventative measures to alleviate the life-threatening complications of type 2 diabetes. Hederasaponin C (PB5), a natural product, has been reported to exhibit significant therapeutic effects in various diseases; however, the possible effects and […]

Advances in nanoscale carrier-based approaches to reduce toxicity and enhance efficacy of podophyllotoxin

Announcing a new publication for Acta Materia Medica journal. Podophyllotoxin (PPT), an aryltetralin-type lignan isolated from Podophyllum species, exhibits a wide range of biologic and pharmacologic activities, and mainly serves as an antiviral agent or antitumor drug in clinical applications. However, the therapeutic potential of PPT has been hindered due to its detrimental systemic toxicity, poor solubility, […]

PROTACs targeting epigenetic proteins

Announcing a new publication for Acta Materia Medica journal.  The field of epigenetics pertains to alterations in gene function that are inherited without changes in the DNA sequence, including histone modifications, post-translational modifications of amino acids, and covalent modifications of DNA bases. These alteration pathways modulate the transformation of genotypes into specific phenotypes. Epigenetics plays […]

Photoredox-catalyzed reaction as a powerful tool for rapid natural product Gem-dimethylation modification: discovery of potent anti-cancer agents with improved druggability

Announcing a new publication for Acta Materia Medica journal. Tylophorine has diverse biological activities; however, the stability, solubility, and central nervous system toxicity have severely limited use of tylophorine. The gem-dimethyl group is an organic chemistry functional group that consists of two methyl groups bonded to the same carbon atom. This feature has gained significant attention […]

Structure-based virtual screening for novel p38 MAPK inhibitors and a biological evaluation

Announcing a new publication for Acta Materia Medica journal. Mitogen-activated protein kinases (MAPKs) are a group of serine-threonine protein kinases that can be activated by extracellular stimuli. MAPK14 (p38α) affects major disease processes, while inhibition of p38α has been shown to have potential therapeutic effects. Many inhibitors targeting p38α have entered clinical trials but have […]

Prognostic value and immune infiltration analyses of cuproptosis-related genes in hepatocellular carcinoma

Announcing a new publication for Acta Materia Medica journal. The role of cuproptosis, a newly discovered form of programmed cell death, remains poorly understood in hepatocellular carcinoma (HCC). This study described by this article was aimed at constructing a novel cuproptosis model for analyzing the clinical features, mutation characteristics and immune profile of HCC associated […]