The discovery of new drugs is among humanity’s most sophisticated and cutting-edge intellectual activities. This process requires not only the discovery of the basic laws governing biological activities with curiosity, but also the inspirational creation of new materials, and decades of persistence in the face of difficulties and failures. View the article.
This work predicted and analyzed the protein structures of three monkeypox virus proteomes. Among them, some proteins contain the potential small-molecule-binding sites or conserved antigenic epitope for developing anti-monkeypox agents. View the article.
A biothiol-activated near-infrared (NIR) fluorescence hydrogen sulfide (H2S) donor, PRO-ST, was synthesized and used for real-time visualization of H2S release. PRO-ST may serve as a promising lead donor for real-time promotion of anti-inflammatory effects and wound healing in biological systems. View the article
A smart stimuli-responsive SN38 prodrug nanoassembly for efficient cancer therapy is reported. SN38 prodrug nanoassemblies provide multiple therapeutic advances including ultrahigh drug loading, good colloidal stability, tumor-specific drug release, and high cellular uptake, thereby potently inhibiting colon cancer growth without causing systemic toxicity. View the article
LCP-NP, a lipid calcium phosphate nanoparticle encapsulating STING agonist, exhibits efficient delivery of cGAMP and holds promising potential as a delivery system for immunotherapy in neuroblastoma. View the article.