Tag: localization

MiR-128-3p mediates MRP2 internalization in estrogen-induced cholestasis through targeting PDZK1

Announcing a new publication for Acta Materia Medica journal. Estrogens have been reported to cause dysfunction in biliary transport systems, thereby inducing cholestasis. Multidrug resistance-associated protein 2 (MRP2) is a transporter responsible for independent bile flow. Emerging evidence indicates that PDZ domain containing 1 (PDZK1) regulates localization of MRP2; however, PDZK1’s role and regulatory machinery […]

Molecular mechanisms of transporter regulation and their impairment in intrahepatic cholestasis

Announcing a new publication for Acta Materia Medica journal. Intrahepatic cholestasis (IC) is a liver disease caused by disorders in bile formation and excretion, owing to structural and functional abnormalities in hepatocytes and/or bile capillaries. IC is commonly caused by hepatitis virus, alcohol consumption, drug-induced liver damage, autoimmune liver disease and heredity. In the absence […]