Molecular mechanisms of transporter regulation and their impairment in intrahepatic cholestasis

Announcing a new publication for Acta Materia Medica journal. Intrahepatic cholestasis (IC) is a liver disease caused by disorders in bile formation and excretion, owing to structural and functional abnormalities in hepatocytes and/or bile capillaries. IC is commonly caused by hepatitis virus, alcohol consumption, drug-induced liver damage, autoimmune liver disease and heredity. In the absence of effective treatment, IC can progress to liver fibrosis, cirrhosis and ultimately liver failure. However, the mechanisms underlying IC remain poorly understood. IC is believed to be closely associated with changes in the transcription, function and localization of hepatocellular transport proteins. To better understand the molecular mechanisms of transport proteins in IC, the authors of this article reviewed the roles of these transport proteins and discussed their underlying regulatory mechanisms in IC to provide a reference for understanding IC pathogenesis and developing effective drug therapies.

Article Reference: Xiping Li, Yue Zu and Guodong Li et al. Molecular mechanisms of transporter regulation and their impairment in intrahepatic cholestasis. Acta Materia Medica. Vol. 1(3):381-391. DOI: 10.15212/AMM-2022-0029

Keywords: intrahepatic cholestasis, transport proteins, localization, regulation

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