Announcing a new publication for Acta Materia Medica journal. Activation of simulator of interferon genes (STING), which induces the production of proinflammatory factors and immune effector cell activation, is considered a promising strategy for enhanced anti-cancer intervention. However, several obstacles prevent STING signaling in solid tumors, such as delivered molecules’ rapid degradation, restriction to tumor […]
Category: News and Events
Cuproptosis-related MTF1 inhibits kidney renal clear cell carcinoma progression by suppressing proliferation and regulating immune cell infiltration
Announcing a new publication for Acta Materia Medica journal. Cuproptosis is a newly identified specific form of programmed cell death. This study aims to identify cuproptosis-related genes (CRGs) in patients with kidney renal clear cell carcinoma (KIRC) from the Cancer Genome Atlas database and to evaluate CRG biological functions. Using lasso regression, four KIRC prognosis-associated […]
Senescence-associated lncRNAs indicate distinct molecular subtypes associated with prognosis and androgen response in patients with patients with prostate cancer
Announcing a new publication for Acta Materia Medica journal. Cellular senescence has been considered as a hallmark of aging. The authors of this article aimed to establish two novel prognostic subtypes for prostate cancer patients using senescence-related lncRNAs. Nonnegative matrix factorization algorithm was used to identify molecular subtypes. Analyses were completed using software R 3.6.3 […]
Recent advances in the molecular design and applications of proteolysis targeting chimera-based multi-specific antiviral modality
Announcing a new publication for Acta Materia Medica journal. Viral infections represent a major threat to human health and the global economy; however, most of the currently available antiviral drugs are not fully effective in restricting viral replication and selecting for drug-resistant variants. Targeted protein degradation technologies are promising strategies to avoid or delay the […]
Aging and cancer hallmarks as therapeutic targets
Announcing a new publication for Acta Materia Medica journal. The prevalence of age-related diseases has been progressively increasing worldwide. The pathogenesis of these disorders, including cancer, is closely associated with an age-dependent decline in cellular functions. There are multiple layers of crosstalk between aging processes and oncogenesis. Therefore, a better understanding of the interplay between […]
1,7-Bis(4-hydroxyphenyl)-1,4,6-heptatrien-3-one inhibits SARS-CoV-2 by targeting the nucleocapsid protein
Announcing a new publication for Acta Materia Medica journal. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread globally since 2020. The nucleocapsid (N) protein plays a crucial role in the life cycle of SARS-CoV-2. The authors of this article have established a method to screen inhibitors of N protein by using microscale thermophoresis assays […]
ZnPc photosensitizer-loaded peony-shaped FeSe 2 remotely controlled by near-infrared light for antimycobacterial therapy
Announcing a new publication for Acta Materia Medica journal. The development of novel antimicrobial agents is highly desirable for treating bacterial infections. The authors of this article constructed a smart photodynamic therapy (PDT) system based on a combination of peony-shaped ferroselite FeSe2 particles and zinc (II) phthalocyanine (ZnPc) photosensitizers. Effective energy transfer occurred from ZnPc to […]
STING agonist delivery by lipid calcium phosphate nanoparticles enhances immune activation for neuroblastoma
Announcing a new publication for Acta Materia Medica journal. Neuroblastoma (NB) is a common solid tumor in children and infants, the formation and regression of which is closely linked to the tumor-host immune relationship. Stimulator of interferon genes (STING) agonists, particularly cyclic dinucleotide (CDN), have promising potential in NB therapy by generating innate and adaptive […]
Efgartigimod, an FcRn antagonist, as a potential treatment for post COVID-19 syndrome
Announcing a new publication for Acta Materia Medica journal. A significant proportion of patients who survive COVID-19 develop a constellation of life-altering symptoms that persist long after the initial infection has resolved. This post-COVID-19 syndrome may result from the development of autoreactive IgG antibodies that cause inflammation and tissue injury. The authors of this article […]
Biological functions and therapeutic potential of acylation by histone acetyltransferases
Announcing a new publication for Acta Materia Medica journal. Histone lysine acylation is a major class of histone post-translational modifications involved in essential biological activities, such as transcriptional regulation, DNA-damage repair, and cell-cycle progression. Abnormal acylation is strongly associated with various diseases, such as cancer. Thus, histone acetyltransferases (HATs), the “writers” that catalyze histone acylation, […]