Category: News and Events

Advances in nanoscale carrier-based approaches to reduce toxicity and enhance efficacy of podophyllotoxin

Announcing a new publication for Acta Materia Medica journal. Podophyllotoxin (PPT), an aryltetralin-type lignan isolated from Podophyllum species, exhibits a wide range of biologic and pharmacologic activities, and mainly serves as an antiviral agent or antitumor drug in clinical applications. However, the therapeutic potential of PPT has been hindered due to its detrimental systemic toxicity, poor solubility, […]

PROTACs targeting epigenetic proteins

Announcing a new publication for Acta Materia Medica journal.  The field of epigenetics pertains to alterations in gene function that are inherited without changes in the DNA sequence, including histone modifications, post-translational modifications of amino acids, and covalent modifications of DNA bases. These alteration pathways modulate the transformation of genotypes into specific phenotypes. Epigenetics plays […]

Photoredox-catalyzed reaction as a powerful tool for rapid natural product Gem-dimethylation modification: discovery of potent anti-cancer agents with improved druggability

Announcing a new publication for Acta Materia Medica journal. Tylophorine has diverse biological activities; however, the stability, solubility, and central nervous system toxicity have severely limited use of tylophorine. The gem-dimethyl group is an organic chemistry functional group that consists of two methyl groups bonded to the same carbon atom. This feature has gained significant attention […]

Structure-based virtual screening for novel p38 MAPK inhibitors and a biological evaluation

Announcing a new publication for Acta Materia Medica journal. Mitogen-activated protein kinases (MAPKs) are a group of serine-threonine protein kinases that can be activated by extracellular stimuli. MAPK14 (p38α) affects major disease processes, while inhibition of p38α has been shown to have potential therapeutic effects. Many inhibitors targeting p38α have entered clinical trials but have […]

Prognostic value and immune infiltration analyses of cuproptosis-related genes in hepatocellular carcinoma

Announcing a new publication for Acta Materia Medica journal. The role of cuproptosis, a newly discovered form of programmed cell death, remains poorly understood in hepatocellular carcinoma (HCC). This study described by this article was aimed at constructing a novel cuproptosis model for analyzing the clinical features, mutation characteristics and immune profile of HCC associated […]

Sesquiterpenoids from the sunflower family as potential anti-inflammatory candidates

Announcing a new publication for Acta Materia Medica journal.  Inflammation is an essential part of the immune response to injury and infection. Emerging evidence indicates that long-term low-grade inflammation is positively correlated with many diseases, such as cancer, metabolic disorders, and cardiovascular diseases. Due to common anti-inflammatory drugs are suitable for treating acute inflammation and […]

Baseline differences in metabolic profiles of patients with lung squamous cell carcinoma responding or not responding to treatment with nanoparticle albumin-bound paclitaxel (nab-paclitaxel)

Announcing a new publication for Acta Materia Medica journal. Nanoparticle albumin-bound paclitaxel (nab-paclitaxel) is a preparation widely used in chemotherapy for cancers. However, only some patients benefit from this treatment. Therefore, identifying which patients will respond to nab-paclitaxel therapy is crucial. A cohort of 32 patients with lung squamous cell carcinoma (LUSC) treated with nab-paclitaxel […]

An intrinsic connection between COVID-19 and aging

Announcing a new publication for Acta Materia Medica journal. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused a rapidly spreading outbreak of coronavirus disease 2019 (the COVID-19 pandemic). COVID-19 has severely affected healthcare systems worldwide, as well as the global economy, and has significantly increased morbidity and mortality rates. The majority of COVID-19-related deaths occurred […]

Acta Materia Medica now indexed by Directory of Open Access Journals (DOAJ)

We are delighted to announce that Acta Materia Medica is now indexed by the Directory of Open Access Journals (DOAJ). DOAJ is a community-curated online directory that indexes and provides access to high-quality, open access, peer-reviewed journals and has a reputation for advocating best practices and standards in open access. To be indexed within DOAJ […]

Novel emerging nano-assisted anti-cancer strategies based on the STING pathway

Announcing a new publication for Acta Materia Medica journal.  Activation of simulator of interferon genes (STING), which induces the production of proinflammatory factors and immune effector cell activation, is considered a promising strategy for enhanced anti-cancer intervention. However, several obstacles prevent STING signaling in solid tumors, such as delivered molecules’ rapid degradation, restriction to tumor […]