Announcing a new publication for Acta Materia Medica journal. The prevalence of depressive-like behavior is significantly higher in patients with cholestatic liver disease, leading to a notable reduction in the quality of life. This situation underscores the urgent need to investigate the mechanisms underlying the association between cholestasis and clinical depression. This review provides a […]
Announcing a new publication for Acta Materia Medica journal. The concept of food and medicine homology (FMH) is deeply embedded in traditional Chinese medicine and carries historical importance. The recent rigorous definition of FMH pertains to substances that exhibit both pharmacological and nutritional functions and have active ingredients that are fundamentally non-toxic and appropriate for […]
Announcing a new publication for Acta Materia Medica journal. Excessive consumption of acetaminophen (APAP) has emerged as the primary culprit behind drug-induced liver injury (DILI), with N-acetylcysteine serving as the principal antidote. However, use of N-acetylcysteine is limited to the early stages of APAP-induced DILI and may cause adverse side effects. Consequently, it is imperative […]
Announcing a new publication for Acta Materia Medica journal. Icaritin (ICA) is a prenylflavonoid natural product extracted from plants of the Epimedium genus. The approval of ICA softgel capsules as a class 1.2 traditional Chinese medicine (TCM) innovative drug represents a major advancement offering a novel therapeutic approach for patients with advanced hepatocellular carcinoma (HCC). Class […]
Announcing a new publication for Acta Materia Medica journal. Isosteviol and its derivatives, diterpene compounds with a wide range of biological activities, play important antiviral, antibacterial, antioxidant, antitumor, analgesic, anti-inflammatory, antipyretic, antifungal, and anticardiovascular disease roles. Because of its unique diterpene skeleton, isosteviol is frequently used as an active framework in drug synthesis, thus helping […]
Announcing a new publication for Acta Materia Medica journal. Single-cell RNA sequencing (scRNA-seq) data from published datasets were obtained to investigate the expression and dysregulation of RNA-binding proteins (RBPs), which are critical for alternative mRNA splicing and translational control in rheumatoid arthritis (RA). How RBP regulation differs between RA and osteoarthritis (OA) was examined using […]
Announcing a new publication for Acta Materia Medica journal. Estrogens have been reported to cause dysfunction in biliary transport systems, thereby inducing cholestasis. Multidrug resistance-associated protein 2 (MRP2) is a transporter responsible for independent bile flow. Emerging evidence indicates that PDZ domain containing 1 (PDZK1) regulates localization of MRP2; however, PDZK1’s role and regulatory machinery […]
Announcing a new publication for Acta Materia Medica journal. The binding affinity of aptamers to targets has a crucial role in the pharmaceutical and biosensing effects. Despite diverse post-systematic evolution of ligands by exponential enrichment (post-SELEX) modifications explored in aptamer optimization, accurate prediction of high-affinity modification strategies remains challenging. Sclerostin, which antagonizes the Wnt signaling […]
Announcing a new publication for Acta Materia Medica journal. Prostate cancer (PrCa) is the most prevalent urogenital cancer affecting men. PrCa is marked by uncontrolled cellular growth that leads to abnormal enlargement of the prostate gland. The metastatic spread of PrCa is the primary cause of mortality, causing cancer cell dissemination to distant sites, such […]
Announcing a new publication for Acta Materia Medica journal. Epithelial cell adhesion molecule (EpCAM) is a biomarker for epithelial cell-derived tumors. However, the specific role of EpCAM itself in early-stage hepatocellular carcinoma progression remains unclear, and small molecules targeting EpCAM have not yet been reported. This article discusses how the protein expression profile of EpCAM […]