Announcing a new publication for Acta Materia Medica journal. Oxidative stress is an important pathogenic mechanism in degenerative diseases such as Alzheimer’s disease. Although ginsenoside compound K (CK) is protective against neuronal oxidative damage, the underlying mechanism remains to be understood. In this article, the protective effects of ginsenoside CK against oxidative stress damage induced […]
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The direct STAT3 inhibitor 6-ethoxydihydrosanguinarine exhibits anticancer activity in gastric cancer
Announcing a new publication for Acta Materia Medica journal. Signal transducer and activator of transcription 3 (STAT3) plays a key role in promoting tumor malignant progression. Suppression of hyperactivated STAT3 signaling has emerged as a potential therapeutic strategy for many cancer types. In this article, the effect of 6-ethoxydihydrosanguinarine (6-EDS), a secondary transformation product formed […]
Molecular mechanisms of transporter regulation and their impairment in intrahepatic cholestasis
Announcing a new publication for Acta Materia Medica journal. Intrahepatic cholestasis (IC) is a liver disease caused by disorders in bile formation and excretion, owing to structural and functional abnormalities in hepatocytes and/or bile capillaries. IC is commonly caused by hepatitis virus, alcohol consumption, drug-induced liver damage, autoimmune liver disease and heredity. In the absence […]
MDM2-BCL-X L PROTACs enable degradation of BCL-X L and stabilization of p53
Announcing a new publication for Acta Materia Medica journal. Inhibition or degradation of the anti-apoptotic protein BCL-XL is a viable strategy for cancer treatment. Despite the recent development of PROTACs for degradation of BCL-XL, the choice of E3 ligase has been restricted to VHL and CRBN. The authors of this article report the development of MDM2-BCL-XL PROTACs […]
Statistical evaluation of absolute change versus responder analysis in clinical trials
Announcing a new publication for Acta Materia Medica journal. In clinical trials, the primary analysis is often either a test of absolute/relative change in a measured outcome or a corresponding responder analysis. Although each of these tests may be reasonable, determining which test is most suitable for a particular research study remains an open question. […]
Establishment of a protein thermal shift chip (PTSC) for COVID-19 and exploration of the future of protein chips in pharmacology
Announcing a new review article publication for Acta Materia Medica journal. Traditional protein chips are based on solid chips and cannot enable drug and target screening in a label-free manner. The authors of this article propose a protein thermal shift chip (PTSC) based on fluorescence signals, which enables low-cost, high-throughput, label-free screening. The authors developed […]
Silybin has therapeutic efficacy against non-small cell lung cancer through targeting of Skp2
Announcing a new review article publication for Acta Materia Medica journal. Silybin (SB), a natural flavonoid isolated from Silybum marianum, has been used to treat hepatic fibrosis in clinical settings and as a dietary supplement, because of its hepatoprotective potential. Numerous studies have shown that SB also exerts promising anticancer effects; however, the anticancer targets of […]
Factors associated with pharmacists’ knowledge regarding high-alert medications: a convenience sample survey in China
Announcing a new review article publication for Acta Materia Medica journal. The consequences of medication errors are more severe for high-alert medications than general drugs. Improving pharmacists’ knowledge regarding high-alert medications is important to increase drug safety and maintain patient health. This article reports a study aimed at understanding Chinese hospital pharmacists’ knowledge regarding high-alert […]
Brusatol modulates diverse cancer hallmarks and signaling pathways as a potential cancer therapeutic
Announcing a new review article publication for Acta Materia Medica journal. Cancer is a consequence of uncontrolled cell proliferation that is associated with cell-cycle disruption. It is a multifactorial disease that depends on the modulation of numerous oncogenic signaling pathways and targets and is a major cause of death worldwide. Because of the development of […]
Structure prediction of the entire proteome of monkeypox variants
Announcing a new review article publication for Acta Materia Medica journal. Recently, the monkeypox virus has begun to spread in many countries worldwide. The genome sequence of the monkeypox virus variant responsible for the current outbreak has been reported, thus providing an important resource for better understanding the new variant and accelerating vaccine and drug […]