Announcing a new publication for Acta Materia Medica journal. Osteosarcoma, a primary malignant tumor of the skeleton, has a morbidity of 2.5 per 1 million people. The epiphysis of extremities is typically affected. Osteosarcoma has a high likelihood of early metastasis, rapid progression, and poor prognosis. The survival rate of patients with metastatic or recurrent […]
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Cancer treatment: from traditional Chinese herbal medicine to the liposome delivery system
Announcing a new publication for Acta Materia Medica journal. Traditional Chinese herbal (TCH) medicines have emerged as a prospective and affordable method to treat various diseases with a broad range of biological activity; however, traditional preparations, like decoctions, are often associated with low bioavailability, thus resulting in limited efficacy against cancer. The drawbacks of active […]
Biothiol-triggered H2S release from a near-infrared fluorescent H2S donor promotes cutaneous wound healing
Announcing a new publication for Acta Materia Medica journal. Hydrogen sulfide (H2S) plays crucial roles in antioxidation, anti-inflammation, and cytoprotection. Despite substantial progress in the design and synthesis of activatable H2S donors, methods for high-precision detection and imaging of released H2S in living systems have been lacking. In this study, a biothiol-activated near-infrared (NIR) fluorescent […]
Cytotoxic compounds from marine actinomycetes: sources, structures and bioactivity
Announcing a new publication for Acta Materia Medica journal. Marine actinomycetes produce a substantial number of natural products with cytotoxic activity. Actinomycete strains have been isolated from sources including fishes, coral, sponges, seaweeds, mangroves and sediments. These cytotoxic compounds can be broadly categorized into four classes: polyketides; non-ribosomal peptides and hybrids; isoprenoids and hybrids; and […]
Structurally diverse polydopamine-based nanomedicines for cancer therapy
Announcing a new publication for Acta Materia Medica journal. Mussel-inspired polydopamine (PDA) has attracted substantial interest in materials synthesis, energy storage, environmental governance, and biomedical science since it was first reported in 2007. PDA, owing to its excellent biocompatibility and photothermal conversion efficiency (η), has been used in photothermal therapy alone and in combination with […]
Recent progress in cancer therapy based on the combination of ferroptosis with photodynamic therapy
Announcing a new publication for Acta Materia Medica journal. Current anticancer treatments have many limitations to achieving high efficacy. Hence, novel strategies that broaden therapeutic prospects must urgently be developed. Ferroptosis is an iron-dependent form of non-apoptotic programmed cell death that is induced by cellular antioxidative system inhibition. Photodynamic therapy (PDT) uses photosensitizers to generate […]
In vitro characterization and cellular uptake profiles of TAMs-targeted lipid calcium carbonate nanoparticles for cancer immunotherapy
Announcing a new publication for Acta Materia Medica journal. Tumor-associated macrophages (TAMs) are key contributors to tumor development, accelerated tumor invasion and metastasis, and induction of immunosuppression. Targeted delivery of immunomodulatory agents to promote polarization of TAMs may alleviate the immunosuppressive tumor microenvironment. Calcium carbonate nanoparticles (CCN), which exhibit excellent biocompatibility, pH sensitivity, and easy […]
Protective effects of ginsenoside CK against oxidative stress-induced neuronal damage, assessed with 1H-NMR-based metabolomics
Announcing a new publication for Acta Materia Medica journal. Oxidative stress is an important pathogenic mechanism in degenerative diseases such as Alzheimer’s disease. Although ginsenoside compound K (CK) is protective against neuronal oxidative damage, the underlying mechanism remains to be understood. In this article, the protective effects of ginsenoside CK against oxidative stress damage induced […]
The direct STAT3 inhibitor 6-ethoxydihydrosanguinarine exhibits anticancer activity in gastric cancer
Announcing a new publication for Acta Materia Medica journal. Signal transducer and activator of transcription 3 (STAT3) plays a key role in promoting tumor malignant progression. Suppression of hyperactivated STAT3 signaling has emerged as a potential therapeutic strategy for many cancer types. In this article, the effect of 6-ethoxydihydrosanguinarine (6-EDS), a secondary transformation product formed […]
Molecular mechanisms of transporter regulation and their impairment in intrahepatic cholestasis
Announcing a new publication for Acta Materia Medica journal. Intrahepatic cholestasis (IC) is a liver disease caused by disorders in bile formation and excretion, owing to structural and functional abnormalities in hepatocytes and/or bile capillaries. IC is commonly caused by hepatitis virus, alcohol consumption, drug-induced liver damage, autoimmune liver disease and heredity. In the absence […]