Advances in microneedle patches for long-acting contraception

Announcing a new publication for Acta Materia Medica journal.   Despite the advances in contraceptives, there is still a high rate of unintended pregnancies worldwide, due in large part to the lack of effective, convenient, and safe birth control methods. Compared with short-acting contraceptives, approaches that offer long-term pregnancy protection have attracted greater interest because of the reduced dosing frequency and improved patient compliance. As a novel transdermal drug delivery system, the microneedle (MN) patch has been widely used for a variety of biomedical applications, including long-acting contraception, due to unique properties, such as painless self-administration and elimination of biohazardous waste. In this article the authors provide a systemic review of MN patches that have been utilized for long-term contraception, including dissolvable MN patches, polymeric biodegradable MN patches, and silk fibroin-based biodegradable MN patches. The acceptability and biosafety of these contraceptive MN patches are also discussed. Finally, perspectives on the future clinical translation of MN patches for long-acting contraception are given.

Keywords: Contraception, microneedle patch, long-acting, sustained release

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Article Reference: Xue Jiang, Yongnian Zeng and Wen Zhang et al. Advances in microneedle patches for long-acting contraception. Acta Materia Medica. Vol. 2(1):1-8. DOI: 10.15212/AMM-2022-0042