Announcing a new publication for Acta Materia Medica journal. Organoids are three-dimensional cell accusations generated from pluripotent stem cells or adult stem cells in vitro. With many advantages over cell and animal models, organoids have been increasingly used in drug and clinical medical research in recent years. Chinese herbal medicine (CHM) is characterized by multi-target and […]
Category: News and Events
Computational strategies for PROTAC drug discovery
Announcing a new publication for Acta Materia Medica journal. Proteolysis-targeting chimeras (PROTACs), a novel targeted protein degradation technology for potential clinical drug discovery, is composed of a protein-targeting ligand covalently linked to an E3 ligase ligand. Through recruiting E3 ligase to target proteins, PROTACs elicit ubiquitination and subsequent degradation of targets via the ubiquitin-proteasome system. […]
Recent advances in nano-targeting drug delivery systems for rheumatoid arthritis treatment
Announcing a new publication for Acta Materia Medica journal. Rheumatoid arthritis is a systemic inflammatory disease that can lead to articular cartilage destruction and periarticular bone erosion, thus ultimately compromising joint integrity and function. Anti-inflammatory drugs and biological agents are commonly used to treat rheumatoid arthritis, but they cannot selectively target inflamed joints, because of […]
Efficacy of corticosteroids as an adjunctive therapy in the treatment of community-acquired pneumonia
Announcing a new publication for Acta Materia Medica journal. The objective of this study was to systematically evaluate the clinical efficacy of the complementary use of corticosteroids in the treatment of community-acquired pneumonia (CAP). The authors searched all relevant documents in five scientific databases from inception to June 2022 to collect clinical trials (randomized controlled […]
Latent herpes simplex virus type 1 reactivation increases the susceptibility of neurodegenerative diseases intervention with traditional Chinese medicine
Announcing a new publication for Acta Materia Medica journal. Owing to environmental and lifestyle changes in modern society, physical and mental stress is on the rise among the population in attempting to compensate for the changes. Stress, defined as a series of non-specific responses to abnormal internal and external stimuli, has long been recognized to […]
Advances in microneedle patches for long-acting contraception
Announcing a new publication for Acta Materia Medica journal. Despite the advances in contraceptives, there is still a high rate of unintended pregnancies worldwide, due in large part to the lack of effective, convenient, and safe birth control methods. Compared with short-acting contraceptives, approaches that offer long-term pregnancy protection have attracted greater interest because of […]
Mass spectrometry imaging advances and application in pharmaceutical research
Announcing a new publication for Acta Materia Medica journal. Mass spectrometry imaging (MSI) has been shown to be a valuable tool through nearly every stage of the preclinical drug research and development (R&D) pipeline, and even to the early phase of clinical pharmaceutical evaluation. MSI can specifically resolve distributions of a parent drug and its […]
Functions and therapeutic potentials of exosomes in osteosarcoma
Announcing a new publication for Acta Materia Medica journal. Osteosarcoma, a primary malignant tumor of the skeleton, has a morbidity of 2.5 per 1 million people. The epiphysis of extremities is typically affected. Osteosarcoma has a high likelihood of early metastasis, rapid progression, and poor prognosis. The survival rate of patients with metastatic or recurrent […]
Cancer treatment: from traditional Chinese herbal medicine to the liposome delivery system
Announcing a new publication for Acta Materia Medica journal. Traditional Chinese herbal (TCH) medicines have emerged as a prospective and affordable method to treat various diseases with a broad range of biological activity; however, traditional preparations, like decoctions, are often associated with low bioavailability, thus resulting in limited efficacy against cancer. The drawbacks of active […]
Biothiol-triggered H2S release from a near-infrared fluorescent H2S donor promotes cutaneous wound healing
Announcing a new publication for Acta Materia Medica journal. Hydrogen sulfide (H2S) plays crucial roles in antioxidation, anti-inflammation, and cytoprotection. Despite substantial progress in the design and synthesis of activatable H2S donors, methods for high-precision detection and imaging of released H2S in living systems have been lacking. In this study, a biothiol-activated near-infrared (NIR) fluorescent […]