Announcing a new publication for Acta Materia Medica journal. Phosphodiesterase-4 (PDE4), a member of the phosphodiesterase superfamily, has highly important roles in cyclic nucleotide signaling pathways and a variety of skin disorders. Blocking PDE4 activity with PDE4 inhibitors increases intracellular cAMP levels and effectively relieves the skin inflammatory phenotype of psoriasis. However, traditional PDE4 inhibitors […]
Announcing a new publication for Acta Materia Medica journal. Phagocytosis is a fundamental mechanism used by the body to resist pathogens and restore physiological homeostasis. Herein, to identify small molecules with anti-inflammatory properties via phagocytosis inhibition, the authors of this article constructed a library of natural products and evaluated their ability to modulate phagocytosis in […]
Announcing a new publication for Acta Materia Medica journal. Treatment of cancer can be challenging, because of the disease’s intricate and varied nature. Consequently, developing nanomedicines with multimodal therapeutic capabilities for precise tumor therapy holds substantial promise in advancing cancer treatment. Herein, a nanoplatform strategy involving supramolecular photosensitizer (ETSCe6 NPs) and chelated metal ions (Au […]
Announcing a new publication for Acta Materia Medica journal. Monoamine oxidase (MAO) is a useful target in the treatment of neurodegenerative diseases and depressive disorders. Understanding the structure-activity relationship (SAR) and mechanisms underlying MAO inhibitors is crucial but challenging. The coumarin scaffold has been shown to be ideal for MAO inhibitors, yet the SAR for […]
Announcing a new publication for Acta Materia Medica journal. Cordyceps sinensis mycelium culture extract (Cs4) were assessed for alleviating long COVID symptoms. In this randomized trial 110 participants were assigned to receive Cs4 (55 participants) or were waitlisted (55 participants) for 12 weeks. The primary outcome was the change in long COVID symptom severity at 12 […]
Announcing a new publication for Acta Materia Medica journal. The prevalence of depressive-like behavior is significantly higher in patients with cholestatic liver disease, leading to a notable reduction in the quality of life. This situation underscores the urgent need to investigate the mechanisms underlying the association between cholestasis and clinical depression. This review provides a […]
Announcing a new publication for Acta Materia Medica journal. The concept of food and medicine homology (FMH) is deeply embedded in traditional Chinese medicine and carries historical importance. The recent rigorous definition of FMH pertains to substances that exhibit both pharmacological and nutritional functions and have active ingredients that are fundamentally non-toxic and appropriate for […]
Announcing a new publication for Acta Materia Medica journal. Excessive consumption of acetaminophen (APAP) has emerged as the primary culprit behind drug-induced liver injury (DILI), with N-acetylcysteine serving as the principal antidote. However, use of N-acetylcysteine is limited to the early stages of APAP-induced DILI and may cause adverse side effects. Consequently, it is imperative […]
Announcing a new publication for Acta Materia Medica journal. Icaritin (ICA) is a prenylflavonoid natural product extracted from plants of the Epimedium genus. The approval of ICA softgel capsules as a class 1.2 traditional Chinese medicine (TCM) innovative drug represents a major advancement offering a novel therapeutic approach for patients with advanced hepatocellular carcinoma (HCC). Class […]
Announcing a new publication for Acta Materia Medica journal. Isosteviol and its derivatives, diterpene compounds with a wide range of biological activities, play important antiviral, antibacterial, antioxidant, antitumor, analgesic, anti-inflammatory, antipyretic, antifungal, and anticardiovascular disease roles. Because of its unique diterpene skeleton, isosteviol is frequently used as an active framework in drug synthesis, thus helping […]