Announcing a new publication for Acta Materia Medica journal. Epithelial cell adhesion molecule (EpCAM) is a biomarker for epithelial cell-derived tumors. However, the specific role of EpCAM itself in early-stage hepatocellular carcinoma progression remains unclear, and small molecules targeting EpCAM have not yet been reported. This article discusses how the protein expression profile of EpCAM […]
Announcing a new publication for Acta Materia Medica journal. Cardiovascular diseases (CVDs) pose a significant threat to human health due to the high mortality and morbidity rates. Traditional drugs often have limited efficacy due to inherent constraints, such as low bioavailability and notable side effects. As a highly regarded therapeutic strategy, nanotechnology offers new perspectives […]
Announcing a new publication for Acta Materia Medica journal. The UPLC-QqQ-MS/MS method was established, validated, and used for the simultaneous detection of berberine (BBR), astragaloside IV (AST), and the main metabolites to demonstrate the comparative pharmacokinetics of BBR and AST in normal and T2DM rats. BBR and AST had reduced the internal exposure of each […]
Announcing a new publication for Acta Materia Medica journal. Complex biological mechanisms and unidentified therapeutic targets for amyotrophic lateral sclerosis (ALS) significantly hinder the development of effective treatments. Given these challenges, reliable disease models that accurately replicate ALS phenotypes with relevant biological underpinnings are essential for advancing precision medicine in ALS. Patient-derived induced pluripotent stem […]
Announcing a new publication for Acta Materia Medica journal. Kinases have a pivotal role in phosphorylation and kinase dysregulation has been implicated in the occurrence and progression of various diseases. By mid-2024 the Food and Drug Administration had approved 81 small-molecule kinase inhibitors targeting greater than 30 kinases, providing substantial clinical benefits for patients with […]
Announcing a new publication for Acta Materia Medica journal. Phytosomes, a novel drug delivery system, have recently attracted substantial attention, because of their exceptional ability to increase the therapeutic efficacy and bioavailability of phytoconstituents. This article provides a thorough introduction to phytosomes, with emphasis on their formulation methods, assessment, and medicinal uses. Phytosomes are intricate […]
Announcing a new publication for Acta Materia Medica journal. Fatty acid (FA) reprogramming has a significant role in liver cancer. However, the contribution of FA metabolism reprogramming to the heterogeneity of hepatocellular carcinoma (HCC) has not been established. This article describes how bioinformatics analysis using single-cell sequencing, a non-negative matrix factorization (NMF) algorithm, and survival […]
Announcing a new publication for Acta Materia Medica journal. Proteins are essential macromolecules that perform functions according to their conformational dynamics. Studying the conformational changes induced by protein mutations is the standard approach used to understand the mechanisms underlying mutation-related physiological and pathological processes. To enhance efficiency and decrease the expense of biological experiments, this […]
Announcing a new publication for Acta Materia Medica journal. Zeqi (Euphorbia helioscopia L.), is a widely distributed plant of the Euphorbiaceae family. Zeqi is a famous Chinese herbal medicine with the effects of inducing diuresis for removing edema, killing pathogens and relieve itching, etc. It can be used to treat edema, dysentery, osteomyelitis, cancer and […]
Announcing a new publication for Acta Materia Medica journal. Cancer has been a severe public health and social problem, a leading disease that has diminished the quality of life, and a barrier to improving life expectancy. Neocryptolepine is an indole-quinoline alkaloid isolated from Cryptolepis sanguinolenta which grows in some African countries. This article summarizes the structures of […]