Announcing a new publication for Acta Materia Medica journal. Dengue virus (DENV) poses a serious health threat globally for which specific antivirals are not available. Envelope (E) protein and RNA-dependent RNA polymerase (RdRp) from DENV represent the most critical targets for the development of antivirals that inhibit viral adsorption for entry and genome replication, respectively; […]
Announcing a new publication for Acta Materia Medica journal. Meroterpenoids, a class of hybrid natural products derived from both terpenoid and non-terpenoid biosynthetic pathways, serve as a prolific source of drug leads, because of their structural complexity and extensive bioactivities. Meroterpenoids have provided many clinical drugs or promising leads, such as mycophenolic acid (an immunosuppressant), […]
Announcing a new publication for Acta Materia Medica journal. Guanidine alkaloids widely exist in terrestrial microorganisms, peptides, and marine invertebrates, and have a multitude of biological activities. Consequently, these molecules have attracted attention as potential drug leads among chemists and biologists. This review provides an overview of research progress in bioactive guanidine alkaloids since 2012, […]
Announcing a new publication for Acta Materia Medica journal. Bioresponsive materials have gained prominence as innovative tools for advancing drug delivery systems, particularly in managing type 1 and type 2 diabetes mellitus. These materials respond to biological stimuli such as pH, glucose, enzymes, or temperature, thereby enabling spatiotemporally controlled drug release. This article examines recent […]
Announcing a new publication for Acta Materia Medica journal. Geroprotectors that delay aging have substantial potential for preventing and mitigating age-related diseases. Natural products derived from traditional herbal medicines are promising candidates for geroprotector discovery, because of their multi-target mechanisms and preventive health benefits. Through screening of 836 Chinese herbal medicine extracts, it was identified […]
Announcing a new publication for Acta Materia Medica journal. Proteins of the gasdermin family are executors of pyroptosis. Upon cleavage-dependent/independent activation, gasdermins form pores on the cell membrane, which damage the integrity of the cell membrane and lead to pro-inflammatory cellular content release and lytic cell death. The role of gasdermin in pyroptosis-associated diseases, such […]
Announcing a new publication for Acta Materia Medica journal. The prevalence of diabetes is increasing and expected to become a major global health burden. Various pharmaceutical approaches have been used to manage diabetes and reduce the associated risks. Subcutaneous insulin injection remains the primary treatment due to the physicochemical properties of insulin, which limit oral […]
Announcing a new publication for Acta Materia Medica journal. In addition to regulating lipid biosynthesis and uptake, sterol regulatory element binding protein (SREBP) is involved in mediating biological signaling networks. SREBP is a key transcription factor in the regulation of physiologic and pathologic lipid metabolism processes. “SREBP” was used as a keyword in searches on […]
Announcing a new publication for Acta Materia Medica journal. Neurologic disorders are the leading cause of illness and disability as a result of increased life expectancy and global population aging, highlighting the urgent need and great challenge for discovering neuroprotective agents with better efficacy and minimal side-effects. Catalpol, an iridoid glycoside derived from Rehmanniae Radix, […]
Announcing a new publication for Acta Materia Medica journal. Proteolysis targeting chimera (PROTAC) technology has emerged as a powerful tool in drug discovery that enables targeted protein degradation through a unique bifunctional approach. This review provides a comprehensive overview of PROTACs with a focus on recent advances in enhancing selectivity and therapeutic potential. We begin […]