Announcing a new publication for Acta Materia Medica journal. S phase kinase-associated protein 2 (SKP2), the rate-limiting substrate receptor of the SKP1-Cullin1-F-box (SCF) E3 ubiquitin ligase complex, is considered a canonical gatekeeper of cell cycle progression. However, accumulating evidence indicates that SKP2 functions as a multifaceted signaling hub that orchestrates metabolic reprogramming, the DNA damage […]
Announcing a new publication for Acta Materia Medica journal. Despite therapeutic advances, long-term psoriasis management remains challenged by cost, immunogenicity, and administration barriers. Although the anti-inflammatory properties of avicularin (AL) are recognized, its direct targeting of IL-17RA and its therapeutic efficacy in psoriasis remain unreported. The authors of this article established the efficacy of Euphorbia humifusa Willd. […]
Announcing a new publication for Acta Materia Medica journal. The pathogenesis of acute lung injury (ALI) and the severe form of ALI, acute respiratory distress syndrome (ARDS), is incompletely understood. We aimed to determine the mechanism of action for non-muscle myosin heavy-chain IIA (NMMHC IIA) and the NMMHC IIA targeting compound in the context of […]
Announcing a new publication for Acta Materia Medica journal. Inflammation is a complex biological response essential for tissue repair in acute settings, yet chronic dysregulation contributes to progressive tissue damage and the pathogenesis of numerous diseases. Lonicera japonica Thunb. (honeysuckle), a traditional Chinese medicinal herb renowned for its “heat clearing and detoxifying” properties, exhibits multi-target anti-inflammatory […]
Announcing a new publication for Acta Materia Medica journal. Gastrointestinal motility disorders (GIMDs) are characterized by impaired gastrointestinal motility. The prevention and treatment of GIMDs remain challenging, because of their prevalence and complexity. The pathogenesis of GIMDs involves multiple factors, such as dysregulation of the enteric nervous system, smooth muscle dysfunction, neurotransmitter imbalance, chronic inflammation, […]
Announcing a new publication for Acta Materia Medica journal. Diacerein, an anthraquinone derivative, is emerging as a promising disease-modifying agent in rheumatoid arthritis (RA), because of its potent anti-inflammatory and chondroprotective actions. Unlike nonsteroidal anti-inflammatory drugs, which primarily inhibit cyclooxygenase enzymes, diacerein suppresses interleukin-1β, a central mediator of synovial inflammation and cartilage degradation. It also […]
Announcing a new publication for Acta Materia Medica journal. New drug research and development (R&D) faces critical challenges such as drug resistance, ineffectiveness of single-target interventions, “undruggable” targets, long cycles, and high costs. This article analyzes five typical use cases to illustrate breakthrough strategies for addressing these issues. Innovations include the identification of dual-target antibiotics […]
Announcing a new publication for Acta Materia Medica journal. Traditional Chinese medicine (TCM), characterized by multi-component, multi-target, and systemic therapeutic mechanisms, provides unique advantages in managing complex diseases. However, the inherent complexity of TCM formulations, including nonlinear component interactions, elusive compatibility principles, and a lack of quantitative biomarkers, has hindered the systematic elucidation of their […]
Announcing a new publication for Acta Materia Medica journal. Heart failure (HF) remains a major global health challenge with limited therapeutic options, thus prompting the search for novel cardioprotective agents among traditional Chinese medicines. In this study, screening of 828 herbal extracts in an oxygen glucose deprivation injury H9c2 cardiomyocyte model led to the identification […]
Announcing a new publication for Acta Materia Medica journal. The host response to viral infections largely depends on the viral load intensity, and the fluctuating viral kinetics after antiviral treatment should perturb host responses accordingly. Therefore, conventional comparison of individual host factors between virus-infected models with vs without antiviral treatment usually generates biased results that […]