Announcing a new publication for Acta Materia Medica journal. Inflammation is a complex biological response essential for tissue repair in acute settings, yet chronic dysregulation contributes to progressive tissue damage and the pathogenesis of numerous diseases. Lonicera japonica Thunb. (honeysuckle), a traditional Chinese medicinal herb renowned for its “heat clearing and detoxifying” properties, exhibits multi-target anti-inflammatory […]
Announcing a new publication for Acta Materia Medica journal. Gastrointestinal motility disorders (GIMDs) are characterized by impaired gastrointestinal motility. The prevention and treatment of GIMDs remain challenging, because of their prevalence and complexity. The pathogenesis of GIMDs involves multiple factors, such as dysregulation of the enteric nervous system, smooth muscle dysfunction, neurotransmitter imbalance, chronic inflammation, […]
Announcing a new publication for Acta Materia Medica journal. Diacerein, an anthraquinone derivative, is emerging as a promising disease-modifying agent in rheumatoid arthritis (RA), because of its potent anti-inflammatory and chondroprotective actions. Unlike nonsteroidal anti-inflammatory drugs, which primarily inhibit cyclooxygenase enzymes, diacerein suppresses interleukin-1β, a central mediator of synovial inflammation and cartilage degradation. It also […]
Announcing a new publication for Acta Materia Medica journal. New drug research and development (R&D) faces critical challenges such as drug resistance, ineffectiveness of single-target interventions, “undruggable” targets, long cycles, and high costs. This article analyzes five typical use cases to illustrate breakthrough strategies for addressing these issues. Innovations include the identification of dual-target antibiotics […]
Announcing a new publication for Acta Materia Medica journal. Traditional Chinese medicine (TCM), characterized by multi-component, multi-target, and systemic therapeutic mechanisms, provides unique advantages in managing complex diseases. However, the inherent complexity of TCM formulations, including nonlinear component interactions, elusive compatibility principles, and a lack of quantitative biomarkers, has hindered the systematic elucidation of their […]
Announcing a new publication for Acta Materia Medica journal. Heart failure (HF) remains a major global health challenge with limited therapeutic options, thus prompting the search for novel cardioprotective agents among traditional Chinese medicines. In this study, screening of 828 herbal extracts in an oxygen glucose deprivation injury H9c2 cardiomyocyte model led to the identification […]
Announcing a new publication for Acta Materia Medica journal. The host response to viral infections largely depends on the viral load intensity, and the fluctuating viral kinetics after antiviral treatment should perturb host responses accordingly. Therefore, conventional comparison of individual host factors between virus-infected models with vs without antiviral treatment usually generates biased results that […]
Announcing a new publication for Acta Materia Medica journal. Dengue virus (DENV) poses a serious health threat globally for which specific antivirals are not available. Envelope (E) protein and RNA-dependent RNA polymerase (RdRp) from DENV represent the most critical targets for the development of antivirals that inhibit viral adsorption for entry and genome replication, respectively; […]
Announcing a new publication for Acta Materia Medica journal. Meroterpenoids, a class of hybrid natural products derived from both terpenoid and non-terpenoid biosynthetic pathways, serve as a prolific source of drug leads, because of their structural complexity and extensive bioactivities. Meroterpenoids have provided many clinical drugs or promising leads, such as mycophenolic acid (an immunosuppressant), […]
Announcing a new publication for Acta Materia Medica journal. Guanidine alkaloids widely exist in terrestrial microorganisms, peptides, and marine invertebrates, and have a multitude of biological activities. Consequently, these molecules have attracted attention as potential drug leads among chemists and biologists. This review provides an overview of research progress in bioactive guanidine alkaloids since 2012, […]