Announcing a new review article publication for Acta Materia Medica journal. Traditional protein chips are based on solid chips and cannot enable drug and target screening in a label-free manner. The authors of this article propose a protein thermal shift chip (PTSC) based on fluorescence signals, which enables low-cost, high-throughput, label-free screening. The authors developed a PTSC for COVID-19, containing 12 SARS-CoV-2 and host target proteins. A series of quality-control tests were performed for small-molecule drugs, macromolecular antibodies, and herbal-medicine extracts. This chip enabled high-throughput screening of COVID-19 drugs and thus may serve as a tool for screening drug targets clinically effective drugs.
Article Reference: Peng Chen, Zhao Cui and Caifeng Li et al. Establishment of a protein thermal shift chip (PTSC) for COVID-19 and exploration of the future of protein chips in pharmacology. Acta Materia Medica. Vol. 1(3):314-319. DOI: 10.15212/AMM-2022-0016
https://www.scienceopen.com/hosted-document?doi=10.15212/AMM-2022-0016
Keywords: protein thermal shift chip, COVID-19, drug target, pharmacology
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