Announcing a new review article publication for Acta Materia Medica journal. Recently, the monkeypox virus has begun to spread in many countries worldwide. The genome sequence of the monkeypox virus variant responsible for the current outbreak has been reported, thus providing an important resource for better understanding the new variant and accelerating vaccine and drug development. The authors of this article report structure predictions of the whole proteomes of three monkeypox variants, with annotation of potential small-molecule-binding regions of the proteins. Experimentally determined structures with high similarity to monkeypox proteins were vetted through a structure-alignment algorithm.
Article Reference: Liangzhen Zheng, Jintao Meng and Mingzhi Lin et al. Structure prediction of the entire proteome of monkeypox variants. Acta Materia Medica. Vol. 1(2):260-264. DOI: 10.15212/AMM-2022-0017
Keywords: monkeypox, structure prediction, function annotation, structure alignment
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