Tag: structure-activity relationship

Coumarin derivatives as inhibitors against monoamine oxidase: structure-activity relationships and inhibitory mechanisms

Announcing a new publication for Acta Materia Medica journal. Monoamine oxidase (MAO) is a useful target in the treatment of neurodegenerative diseases and depressive disorders. Understanding the structure-activity relationship (SAR) and mechanisms underlying MAO inhibitors is crucial but challenging. The coumarin scaffold has been shown to be ideal for MAO inhibitors, yet the SAR for […]

Structural diversity and biological activities of caged Garcinia xanthones: recent updates

Announcing a new review article publication for Acta Materia Medica journal. Caged xanthones are a class of natural compounds with approximately 200 members that are commonly isolated from the Garcinia genus in the Clusiaceae (formerly Guttiferae) family. They are often characterized by a notable 4-oxatricyclo[ 4.3.1.03,7]dec-2-one (caged) architecture with a common xanthone backbone. Because most […]