Tag: Structural Biology

AF2-mutation: adversarial sequence mutations against AlphaFold2 in protein tertiary structure prediction

Adversarial Sequence Mutations

Announcing a new publication for Acta Materia Medica journal. Proteins are essential macromolecules that perform functions according to their conformational dynamics. Studying the conformational changes induced by protein mutations is the standard approach used to understand the mechanisms underlying mutation-related physiological and pathological processes. To enhance efficiency and decrease the expense of biological experiments, this […]

Solving the mysteries of urate transport: structural insights into GLUT9 and URAT1

Announcing a new publication for Acta Materia Medica journal. Recent groundbreaking advances in the structural biology of the glucose transporter 9 (GLUT9) and urate transporter 1 (URAT1) have provided critical insights into the molecular mechanisms underlying urate recognition and transport. Using cryo-electron microscopy (cryo-EM), researchers have elucidated the structures of these transporters at high resolution, […]