Announcing a new publication for Acta Materia Medica journal. The 3C-like protease (3CLpro) is a crucial target in anti-Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) drug design. The authors of this article performed high-throughput synthesis of catechol derivatives from the bioactive catechol-terminal alkyne scaffold A4, by using modular click chemistry. Subsequently, two rounds of SARS-CoV-2 3CLpro inhibition […]
Tag: sars-cov2
1,7-Bis(4-hydroxyphenyl)-1,4,6-heptatrien-3-one inhibits SARS-CoV-2 by targeting the nucleocapsid protein
Announcing a new publication for Acta Materia Medica journal. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread globally since 2020. The nucleocapsid (N) protein plays a crucial role in the life cycle of SARS-CoV-2. The authors of this article have established a method to screen inhibitors of N protein by using microscale thermophoresis assays […]