Tag: phytochemicals

Euphorbia neriifolia L. extract attenuates heart failure by modulating the Nrf2/ROS/HIF-1α signaling pathway

Announcing a new publication for Acta Materia Medica journal. Heart failure (HF) remains a major global health challenge with limited therapeutic options, thus prompting the search for novel cardioprotective agents among traditional Chinese medicines. In this study, screening of 828 herbal extracts in an oxygen glucose deprivation injury H9c2 cardiomyocyte model led to the identification […]

Benzo-fused ten-membered ring meroterpenoids: sources, chemical diversity, biological activities, and biosynthesis

Announcing a new publication for Acta Materia Medica journal. Meroterpenoids, a class of hybrid natural products derived from both terpenoid and non-terpenoid biosynthetic pathways, serve as a prolific source of drug leads, because of their structural complexity and extensive bioactivities. Meroterpenoids have provided many clinical drugs or promising leads, such as mycophenolic acid (an immunosuppressant), […]