Tag: Pharmacokinetics

Response regression model as a guiding principle for pharmacological mechanistic investigation of host-targeted antivirals

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Announcing a new publication for Acta Materia Medica journal. The host response to viral infections largely depends on the viral load intensity, and the fluctuating viral kinetics after antiviral treatment should perturb host responses accordingly. Therefore, conventional comparison of individual host factors between virus-infected models with vs without antiviral treatment usually generates biased results that […]

Comparative drug-drug interactions of berberine and astragaloside IV in normal and type 2 diabetes mellitus rats based on UPLC-QqQ-MS/MS

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nanozyme-enabled treatment of cardiovascular diseases

Announcing a new publication for Acta Materia Medica journal. The UPLC-QqQ-MS/MS method was established, validated, and used for the simultaneous detection of berberine (BBR), astragaloside IV (AST), and the main metabolites to demonstrate the comparative pharmacokinetics of BBR and AST in normal and T2DM rats. BBR and AST had reduced the internal exposure of each […]