Tag: neurodegeneration

Pathologic and therapeutic insights into cholestatic liver disease-associated depressive disorder

cholestatic liver disease therapeutic

Announcing a new publication for Acta Materia Medica journal. The prevalence of depressive-like behavior is significantly higher in patients with cholestatic liver disease, leading to a notable reduction in the quality of life. This situation underscores the urgent need to investigate the mechanisms underlying the association between cholestasis and clinical depression. This review provides a […]

Druggability, molecular targets, and nanocarrier delivery of natural triterpenoid celastrol against chronic diseases

Announcing a new publication for Acta Materia Medica journal.  Celastrol is an active compound from the root of Tripterygium wilfordii Hook F that shows great potential in the treatment of inflammation, cancer, neurodegeneration, diabetes, and obesity. However, the clinical application of celastrol has been hindered by its low bioavailability and severe systemic toxicity. The aim of this […]