Announcing a new publication for Acta Materia Medica journal. Monoamine oxidase (MAO) is a useful target in the treatment of neurodegenerative diseases and depressive disorders. Understanding the structure-activity relationship (SAR) and mechanisms underlying MAO inhibitors is crucial but challenging. The coumarin scaffold has been shown to be ideal for MAO inhibitors, yet the SAR for […]
Tag: inhibitor
Discovery and characterization of naturally occurring chalcones as potent inhibitors of bile salt hydrolases
Announcing a new review article publication for Acta Materia Medica journal. Bile salt hydrolases (BSHs) play crucial roles in the deconjugation of conjugated bile acids and therefore are key targets for modulating bile acid metabolism. This authors of this article aimed to identify efficacious BSH inhibitors from a natural compound library and to characterize their […]