Announcing a new publication for Acta Materia Medica journal. Celastrol is an active compound from the root of Tripterygium wilfordii Hook F that shows great potential in the treatment of inflammation, cancer, neurodegeneration, diabetes, and obesity. However, the clinical application of celastrol has been hindered by its low bioavailability and severe systemic toxicity. The aim of this […]
Tag: inflammation
Protective role of the curcumin derivative FM0807,in regulating signaling pathways in glomerular mesangial cells and renal function in db db mice
Announcing a new publication for Acta Materia Medica journal. To determine the protective effects of FM0807 against diabetes-induced renal inflammation and fibrosis and the underlying mechanisms in vivo and in vitro. FM0807 was administered to db/db mice. Glomerular mesangial cells (HBZY-1) were cultured under high glucose conditions with or without FM0807. Gene and protein expression was assessed by […]
Sesquiterpenoids from the sunflower family as potential anti-inflammatory candidates
Announcing a new publication for Acta Materia Medica journal. Inflammation is an essential part of the immune response to injury and infection. Emerging evidence indicates that long-term low-grade inflammation is positively correlated with many diseases, such as cancer, metabolic disorders, and cardiovascular diseases. Due to common anti-inflammatory drugs are suitable for treating acute inflammation and […]
Recent advances in nano-targeting drug delivery systems for rheumatoid arthritis treatment
Announcing a new publication for Acta Materia Medica journal. Rheumatoid arthritis is a systemic inflammatory disease that can lead to articular cartilage destruction and periarticular bone erosion, thus ultimately compromising joint integrity and function. Anti-inflammatory drugs and biological agents are commonly used to treat rheumatoid arthritis, but they cannot selectively target inflamed joints, because of […]