Tag: GSDM oligomerization

Advances in gasdermin activation, regulation, and targeted drug development

Advances in gasdermin activation, regulation, and targeted drug development

Announcing a new publication for Acta Materia Medica journal. Proteins of the gasdermin family are executors of pyroptosis. Upon cleavage-dependent/independent activation, gasdermins form pores on the cell membrane, which damage the integrity of the cell membrane and lead to pro-inflammatory cellular content release and lytic cell death. The role of gasdermin in pyroptosis-associated diseases, such […]