Tag: drug discovery

Multi-component Chinese medicine formulas for drug discovery: State of the art and future perspectives

Announcing a new publication for Acta Materia Medica journal. For many years, the drug discovery and development industry has aimed at identifying single components with a clear mechanism of action as desirable candidates for potential drugs. However, this conventional strategy of drug discovery and development has faced challenges including a low success rate and high […]

Acta Materia Medica Call for Papers

Acta Materia Medica provides an open platform for rapid publication of the latest findings, approaches, and viewpoints related to all related areas of pharmacy and pharmaceutical sciences, including, but are not limited to, pharmacology, toxicology, pharmaceutics, medicinal chemistry, natural products, pharmacognosy, pharmaceutical analysis, pharmacokinetics, clinical pharmacy, pharmacoepidemiology, pharmacoeconomics and pharmacy management. Article types accepted: Research […]

PROTAC degraders with ligands recruiting MDM2 E3 ubiquitin ligase: an updated perspective

Announcing a new review article publication for Acta Materia Medica journal.  Mouse double minute 2 (MDM2) is an oncogenic E3 ligase that effectively degrades the tumor suppressor p53. In the past two decades, many MDM2 inhibitors that disrupt MDM2-p53 binding have been discovered and developed. Given that MDM2 and p53 form an auto-regulatory loop, in […]