Tag: Drug Development

Neural network-based elucidation of the mechanisms of asperuloside in osteoarthritis treatment

Graph Neural Networks

Announcing a new publication for Acta Materia Medica journal.    Traditional Chinese medicine has shown therapeutic potential in treating osteoarthritis (OA) by regulating inflammation and maintaining cartilage homeostasis. However, the complex compositions of herbal medicines and the lack of efficient screening strategies have hindered the identification of active compounds and their molecular mechanisms. To address these […]

Artificial intelligence in Traditional Chinese Medicine: systematic insights from data mining, large language models, and multimodal fusion

Announcing a new publication for Acta Materia Medica journal. Traditional Chinese medicine (TCM), characterized by multi-component, multi-target, and systemic therapeutic mechanisms, provides unique advantages in managing complex diseases. However, the inherent complexity of TCM formulations, including nonlinear component interactions, elusive compatibility principles, and a lack of quantitative biomarkers, has hindered the systematic elucidation of their […]

Solving the mysteries of urate transport: structural insights into GLUT9 and URAT1

Announcing a new publication for Acta Materia Medica journal. Recent groundbreaking advances in the structural biology of the glucose transporter 9 (GLUT9) and urate transporter 1 (URAT1) have provided critical insights into the molecular mechanisms underlying urate recognition and transport. Using cryo-electron microscopy (cryo-EM), researchers have elucidated the structures of these transporters at high resolution, […]