Tag: degradation

PROTACs improve selectivity for targeted proteins

Announcing a new publication for Acta Materia Medica journal.  Proteolysis targeting chimera (PROTAC) technology has emerged as a powerful tool in drug discovery that enables targeted protein degradation through a unique bifunctional approach. This review provides a comprehensive overview of PROTACs with a focus on recent advances in enhancing selectivity and therapeutic potential. We begin […]

PROTAC degraders with ligands recruiting MDM2 E3 ubiquitin ligase: an updated perspective

Announcing a new review article publication for Acta Materia Medica journal.  Mouse double minute 2 (MDM2) is an oncogenic E3 ligase that effectively degrades the tumor suppressor p53. In the past two decades, many MDM2 inhibitors that disrupt MDM2-p53 binding have been discovered and developed. Given that MDM2 and p53 form an auto-regulatory loop, in […]