Tag: cardiovascular diseases

Exploring the efficacious subfractions and underlying mechanisms of Herba Siegesbeckiae against myocardial ischemia/reperfusion injury via the UCHL5/NLRP3 pathway

Announcing a new publication for Acta Materia Medica journal.  Herba Siegesbeckiae (HS) has been traditionally used for managing cardio- and cerebro-vascular diseases. Previous studies have demonstrated that HS ameliorates myocardial ischemia/reperfusion (I/R) injury. Also, the differentially expressed proteins between HS and I/R groups were shown to be displayed as UCHL5 and were mainly enriched in […]

Identification of GPR35-associated metabolic characteristics through LC-MS/MS-based metabolomics and lipidomics

Announcing a new publication for Acta Materia Medica journal. G protein-coupled receptor 35 (GPR35) has gained increasing attention as a promising target in treating inflammatory and gastrointestinal tract conditions, cardiovascular diseases, and cancer. Metabolites including kynurenic acid, lysophosphatidic acids, chemokine 17, and 5-hydroxyindole acetic acid have been suggested to be endogenous ligands of GPR35. However, […]

Sesquiterpenoids from the sunflower family as potential anti-inflammatory candidates

Announcing a new publication for Acta Materia Medica journal.  Inflammation is an essential part of the immune response to injury and infection. Emerging evidence indicates that long-term low-grade inflammation is positively correlated with many diseases, such as cancer, metabolic disorders, and cardiovascular diseases. Due to common anti-inflammatory drugs are suitable for treating acute inflammation and […]