Tag: Berberine

Berberine inhibits phagocytosis through the TLR4-PI3K-CDC42 pathway

Announcing a new publication for Acta Materia Medica journal. Phagocytosis is a fundamental mechanism used by the body to resist pathogens and restore physiological homeostasis. Herein, to identify small molecules with anti-inflammatory properties via phagocytosis inhibition, the authors of this article constructed a library of natural products and evaluated their ability to modulate phagocytosis in […]

Comparative drug-drug interactions of berberine and astragaloside IV in normal and type 2 diabetes mellitus rats based on UPLC-QqQ-MS/MS

nanozyme-enabled treatment of cardiovascular diseases

Announcing a new publication for Acta Materia Medica journal. The UPLC-QqQ-MS/MS method was established, validated, and used for the simultaneous detection of berberine (BBR), astragaloside IV (AST), and the main metabolites to demonstrate the comparative pharmacokinetics of BBR and AST in normal and T2DM rats. BBR and AST had reduced the internal exposure of each […]