Tag: Ames tests

Development and validation of DSTOX: an integrated QSAR platform adhering to ICH M7 guidelines for mutagenicity assessment of drug impurities

Mutagenicity

Announcing a new publication for Acta Materia Medica journal.  The assessment of a compound’s potential DNA reactivity (mutagenicity) is a critical component of its safety evaluation. The biological activity of a compound is generally understood to be closely associated with its chemical structure. Because computer-aided quantitative structure-activity relationship (QSAR) models can provide high-throughput and rapid […]