Archives - AMM Journal

Volume 1 (2022)

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The discovery of new drugs is among humanity’s most sophisticated and cutting-edge intellectual activities. This process requires not only the discovery of the basic laws governing biological activities with curiosity, but also the inspirational creation of new materials, and decades of persistence in the face of difficulties and failures. View the article.

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This work predicted and analyzed the protein structures of three monkeypox virus proteomes. Among them, some proteins contain the potential small-molecule-binding sites or conserved antigenic epitope for developing anti-monkeypox agents. View the article.

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As a novel STAT3 inhibitor, 6-ethoxydihydrosanguinarine inhibits the malignant progression of gastric cancer mainly by directly binding to the SH2 domain of STAT3.

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A biothiol-activated near-infrared (NIR) fluorescence hydrogen sulfide (H2S) donor, PRO-ST, was synthesized and used for real-time visualization of H2S release. PRO-ST may serve as a promising lead donor for real-time promotion of anti-inflammatory effects and wound healing in biological systems. View the article

Volume 2 (2023)

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A smart stimuli-responsive SN38 prodrug nanoassembly for efficient cancer therapy is reported. SN38 prodrug nanoassemblies provide multiple therapeutic advances including ultrahigh drug loading, good colloidal stability, tumor-specific drug release, and high cellular uptake, thereby potently inhibiting colon cancer growth without causing systemic toxicity. View the article

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LCP-NP, a lipid calcium phosphate nanoparticle encapsulating STING agonist, exhibits efficient delivery of cGAMP and holds promising potential as a delivery system for immunotherapy in neuroblastoma. View the article.

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N-17 is a diphenylheptane compound isolated from Curcuma kwangsiensis, which exhibits anti-SARS-CoV-2 activity by inhibiting the nucleocapsid protein. View the article.

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Analyzing the impact of PB5 on mouse diabetic models using single-cell sequencing and proteomics reveals kidney cellular heterogeneity and transcriptional responses to DKD and PB5 treatment.

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G protein-coupled receptor 35 (GPR35) interventions had a significant impact on the abundance of downstream metabolites and lipids, particularly affecting those involved in β-oxidation and phosphatidylethanolamine pathways. View the article

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This study explores structural modifications of sodium-glucose cotransporter 2 inhibitors to separate their cardiovascular benefits from glucose-lowering effects. Compound 12, derived from JX22, demonstrated enhanced cardioprotective efficacy and safety in heart failure models without impacting glucose levels. View the article