Announcing a new publication for Acta Materia Medica journal. A preclinical study has developed a precision nano-intervention strategy targeting tumor-associated nerves to destroy nerve-fueled tumor growth in pancreatic cancer. In this strategy, Escherichia coli Nissle 1917-derived outer membrane vesicles (OMVs) are decorated with nerve-binding peptide for targeted delivery of co-loaded tropomyosin receptor kinase (Trk) inhibitors to tumor-associated nerves, thus precisely inhibiting nerve activity through the neurotrophin/Trk signaling pathway. Furthermore, the OMVs trigger M2-M1 switching, thus accelerating nerve injury. This nano-intervention strategy significantly enhances chemotherapy efficacy in pancreatic cancer.
Read full open access articles: https://www.scienceopen.com/hosted-document?doi=10.15212/AMM-2024-0092
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Yutian Xia and Jianzhong Zhang. Boosting pancreatic cancer chemotherapy by disrupting nerve–cancer crosstalk. Acta Materia Medica. 2025. Vol. 4(3):317-320. DOI: 10.15212/AMM-2024-0092