Announcing a new publication for Acta Materia Medica journal. G protein-coupled receptor 35 (GPR35) has gained increasing attention as a promising target in treating inflammatory and gastrointestinal tract conditions, cardiovascular diseases, and cancer.
Metabolites including kynurenic acid, lysophosphatidic acids, chemokine 17, and 5-hydroxyindole acetic acid have been suggested to be endogenous ligands of GPR35. However, little is known regarding the downstream metabolic characteristics upon GPR35 regulation. The authors of this article established four GPR35 interventions in cell models, comprising GPR35 knock-down, over-expression, activation, or inhibition, through lentiviral transduction, or the use of a potent agonist (pamoic acid) or antagonist (ML194). Targeted metabolomics and pseudotargeted lipidomics were performed on these cell models to capture GPR35-associated metabolites and lipids. Levels of 75 metabolites and 204 lipids were significantly altered in response to one or more GPR35 interventions. Levels of metabolites involved in fatty acid β-oxidation and phosphatidylethanolamine metabolism were notably altered.
This study reports the first exploration of the metabolic characteristics of GPR35, and may aid in understanding of the potential mechanisms and functions of GPR35 in various physiological and pathological conditions.
https://www.scienceopen.com/hosted-document?doi=10.15212/AMM-2023-0046
Acta Materia Medica welcomes the submission of research articles, review articles, databases, mini reviews, commentaries, editorials, short communications, case report articles and study protocols.
Submission Process
Submissions to Acta Materia Medica are made using ScholarOne, the online submission and peer review system. Registration and access are available at https://mc04.manuscriptcentral.com/ammed
Queries about the journal can be sent to editorialoffice@amm-journal.org.
Please visit https://amm-journal.org/ to learn more about the journal.
Editorial Board: https://amm-journal.org/index.php/editorial-board/
There are no author submission or article processing fees.
Follow Acta Materia Medica on Twitter https://twitter.com/AMM_journal; Facebook (https://www.facebook.com/AMMjournal)
eISSN 2737-7946
Qiqing Zhang, Xian Zhao and Siyuan Qin et al. Identification of GPR35-associated metabolic characteristics through LC-MS/MS-based metabolomics and lipidomics. Acta Materia Medica. 2024. Vol. 3(1):105-118. DOI: 10.15212/AMM-2023-0046