Announcing a new publication for Acta Materia Medica journal. Meroterpenoids, a class of hybrid natural products derived from both terpenoid and non-terpenoid biosynthetic pathways, serve as a prolific source of drug leads, because of their structural complexity and extensive bioactivities.
Meroterpenoids have provided many clinical drugs or promising leads, such as mycophenolic acid (an immunosuppressant), territrem B (an acetylcholinesterase inhibitor), and pyripyropene A (a cholesterol acyltransferase-2 inhibitor). Recently, meroterpenoids featuring a benzo-fused ten-membered ring skeleton have attracted considerable attention for their unique scaffolds and diverse post-modifications. Bioactivity evaluations have revealed that nearly half of these compounds (32 of 66) exhibit cytotoxicity with half-maximal inhibitory concentrations below 10 μM, and therefore have great potential as drug development candidates, particularly in cancer therapy. However, a systematic summary of this subclass remains lacking.
This article summarizes benzo-fused ten-membered ring meroterpenoids reported between 1980 and 2024, including their sources, structural diversity, bioactivities, and biosynthetic pathways, to provide comprehensive insights to guide further studies on meroterpenoids.
Read More: https://www.scienceopen.com/hosted-document?doi=10.15212/AMM-2025-0029
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eISSN 2737-7946
Wenjie Luo, Ruishan Wang and Danièle Werck-Reichhart et al. Benzo-fused ten-membered ring meroterpenoids: sources, chemical diversity, biological activities, and biosynthesis. Acta Materia Medica. 2025. Vol. 4(4):630-656. DOI: 10.15212/AMM-2025-0029