{"id":977,"date":"2023-10-27T10:45:12","date_gmt":"2023-10-27T10:45:12","guid":{"rendered":"https:\/\/amm-journal.org\/?p=977"},"modified":"2023-10-27T10:45:12","modified_gmt":"2023-10-27T10:45:12","slug":"structure-based-virtual-screening-for-novel-p38-mapk-inhibitors-and-a-biological-evaluation","status":"publish","type":"post","link":"https:\/\/amm-journal.org\/index.php\/2023\/10\/27\/structure-based-virtual-screening-for-novel-p38-mapk-inhibitors-and-a-biological-evaluation\/","title":{"rendered":"Structure-based virtual screening for novel p38 MAPK inhibitors and a biological evaluation"},"content":{"rendered":"

Announcing a new publication for Acta Materia Medica<\/em> journal. Mitogen-activated protein kinases (MAPKs) are a group of serine-threonine protein kinases that can be activated by extracellular stimuli. MAPK14 (p38\u03b1) affects major disease processes, while inhibition of p38\u03b1 has been shown to have potential therapeutic effects. Many inhibitors targeting p38\u03b1 have entered clinical trials but have a long development cycle and severe side effects. The authors of this article developed a multi-step receptor structure-based virtual screening method to screen potential bioactive molecules from SPECS and MCDB libraries. Compound\u00a010<\/strong>\u00a0was identified as a promising p38\u03b1 inhibitor that may be used in the treatment of p38\u03b1MAPK pathway-related diseases, but corollary studies are warranted.<\/p>\n

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Qinwen Zheng, Yumeng Zhu and Aoxue Wang et al. Structure-based virtual screening for novel p38 MAPK inhibitors and a biological evaluation.\u00a0Acta Materia Medica.\u00a0<\/em>2023. Vol. 2(3):377-385. DOI: 10.15212\/AMM-2023-0028<\/p>\n","protected":false},"excerpt":{"rendered":"

Announcing a new publication for Acta Materia Medica journal. Mitogen-activated protein kinases (MAPKs) are a group of serine-threonine protein kinases that can be activated by extracellular stimuli. MAPK14 (p38\u03b1) affects major disease processes, while inhibition of p38\u03b1 has been shown to have potential therapeutic effects. Many inhibitors targeting p38\u03b1 have entered clinical trials but have […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2],"tags":[234,233],"class_list":["post-977","post","type-post","status-publish","format-standard","hentry","category-news-and-events","tag-mapk-inhibitors","tag-protein-kinases"],"yoast_head":"\nStructure-based virtual screening for novel p38 MAPK inhibitors and a biological evaluation - AMM Journal<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/amm-journal.org\/index.php\/2023\/10\/27\/structure-based-virtual-screening-for-novel-p38-mapk-inhibitors-and-a-biological-evaluation\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Structure-based virtual screening for novel p38 MAPK inhibitors and a biological evaluation - AMM Journal\" \/>\n<meta property=\"og:description\" content=\"Announcing a new publication for Acta Materia Medica journal. 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