{"id":925,"date":"2023-09-13T07:49:59","date_gmt":"2023-09-13T07:49:59","guid":{"rendered":"https:\/\/amm-journal.org\/?p=925"},"modified":"2023-09-13T07:49:59","modified_gmt":"2023-09-13T07:49:59","slug":"novel-emerging-nano-assisted-anti-cancer-strategies-based-on-the-sting-pathway","status":"publish","type":"post","link":"https:\/\/amm-journal.org\/index.php\/2023\/09\/13\/novel-emerging-nano-assisted-anti-cancer-strategies-based-on-the-sting-pathway\/","title":{"rendered":"Novel emerging nano-assisted anti-cancer strategies based on the STING pathway"},"content":{"rendered":"

Announcing a new publication for Acta Materia Medica<\/em> journal. \u00a0Activation of simulator of interferon genes (STING), which induces the production of proinflammatory factors and immune effector cell activation, is considered a promising strategy for enhanced anti-cancer intervention. However, several obstacles prevent STING signaling in solid tumors, such as delivered molecules\u2019 rapid degradation, restriction to tumor sites, insufficient intracellular concentrations, and low responsivity. Well-designed, multifunctional nano-formulations have emerged as optimized platforms for STING activation. Recently, a variety of nano-formulations have been developed and used in STING activation, thus facilitating immunotherapy in preclinical and clinical stages. The authors of this article summarize recent advances in nanotechnology-based delivery, activation, and application strategies, which have advanced various aspects of immunotherapy. Novel STING agonists and their mechanisms in STING-activation-mediated tumor interventions are highlighted herein, to provide a comprehensive overview and discuss future directions for boosting immunotherapy via STING regulation.<\/p>\n

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Xianghui Li, Haoran Wang and Yuanyuan Chen et al. Novel emerging nano-assisted anti-cancer strategies based on the STING pathway.\u00a0Acta Materia Medica.\u00a0<\/em>2023. Vol. 2(3):323-341. DOI: 10.15212\/AMM-2023-0023<\/p>\n","protected":false},"excerpt":{"rendered":"

Announcing a new publication for Acta Materia Medica journal. \u00a0Activation of simulator of interferon genes (STING), which induces the production of proinflammatory factors and immune effector cell activation, is considered a promising strategy for enhanced anti-cancer intervention. However, several obstacles prevent STING signaling in solid tumors, such as delivered molecules\u2019 rapid degradation, restriction to tumor […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2],"tags":[214,220,218,219,216,217,215],"class_list":["post-925","post","type-post","status-publish","format-standard","hentry","category-news-and-events","tag-anti-cancer","tag-clinical-translation","tag-controlled-released","tag-immune-microenvironment-modulation","tag-immunotherapy","tag-protection-from-degradation","tag-sting"],"yoast_head":"\nNovel emerging nano-assisted anti-cancer strategies based on the STING pathway - AMM Journal<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/amm-journal.org\/index.php\/2023\/09\/13\/novel-emerging-nano-assisted-anti-cancer-strategies-based-on-the-sting-pathway\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Novel emerging nano-assisted anti-cancer strategies based on the STING pathway - AMM Journal\" \/>\n<meta property=\"og:description\" content=\"Announcing a new publication for Acta Materia Medica journal. \u00a0Activation of simulator of interferon genes (STING), which induces the production of proinflammatory factors and immune effector cell activation, is considered a promising strategy for enhanced anti-cancer intervention. 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