{"id":834,"date":"2023-07-03T09:37:14","date_gmt":"2023-07-03T09:37:14","guid":{"rendered":"https:\/\/amm-journal.org\/?p=834"},"modified":"2023-07-03T09:37:14","modified_gmt":"2023-07-03T09:37:14","slug":"sting-agonist-delivery-by-lipid-calcium-phosphate-nanoparticles-enhances-immune-activation-for-neuroblastoma","status":"publish","type":"post","link":"https:\/\/amm-journal.org\/index.php\/2023\/07\/03\/sting-agonist-delivery-by-lipid-calcium-phosphate-nanoparticles-enhances-immune-activation-for-neuroblastoma\/","title":{"rendered":"STING agonist delivery by lipid calcium phosphate nanoparticles enhances immune activation for neuroblastoma"},"content":{"rendered":"<p>Announcing a new publication for <em>Acta Materia Medica<\/em> journal. \u00a0\u00a0Neuroblastoma (NB) is a common solid tumor in children and infants, the formation and regression of which is closely linked to the tumor-host immune relationship. Stimulator of interferon genes (STING) agonists, particularly cyclic dinucleotide (CDN), have promising potential in NB therapy by generating innate and adaptive immune stimulation, thus leading to tumor control. CDN delivery\u00a0<em>in vivo<\/em>\u00a0is challenging due to the negative charge, hydrophilicity, and susceptibility to degradation by phosphodiesterase, which hinders the effectiveness of CDN. Thus, our study proposed four methods to load CDN into liposomes, using 2\u2032,3\u2032-cGAMP as the model drug. Lipid nanoparticles were prepared, followed by physicochemical characterization. Subsequently, cellular inhibition and immune stimulation were investigated. As a result, lipid calcium phosphate nanoparticles (LCP-NPs) possessed the highest encapsulation efficiency among the four preparation methods, with a diameter of 82.57\u00b13.72 nm. LCP-NPs maintained size stability under refrigeration conditions at 4\u00b0C within 48 h. The surface of the liposome was positively charged. Compared to free cGAMP, LCP-NPs resulted in a slower release, enhanced cytotoxicity against tumor cells, greater activation of the cGAS-STING pathway, and increased expression of the immune factors. Taken together, these findings clearly demonstrated the effectiveness of the liposomal delivery system for cGAMP and provided a promising strategy for the treatment of NB.<\/p>\n<p><a href=\"https:\/\/www.scienceopen.com\/hosted-document?doi=10.15212\/AMM-2023-0011\">https:\/\/www.scienceopen.com\/hosted-document?doi=10.15212\/AMM-2023-0011<\/a><\/p>\n<p><em>Acta Materia Medica<\/em> welcomes the submission of research articles, review articles, databases, mini reviews, commentaries, editorials, short communications, case report articles and study protocols.<\/p>\n<p><strong>Submission Process<\/strong><\/p>\n<p>Submissions <em>to Acta Materia Medica<\/em> are made using ScholarOne, the online submission and peer review system. Registration and access are available at <a href=\"https:\/\/mc04.manuscriptcentral.com\/ammed\">https:\/\/mc04.manuscriptcentral.com\/ammed<\/a><\/p>\n<p>Queries about the journal can be sent to editorialoffice@amm-journal.org.<\/p>\n<p>Please visit <a href=\"https:\/\/amm-journal.org\/\">https:\/\/amm-journal.org\/<\/a> to learn more about the journal.<\/p>\n<p><strong>Editorial Board:<\/strong> <a href=\"https:\/\/amm-journal.org\/index.php\/editorial-board\/\">https:\/\/amm-journal.org\/index.php\/editorial-board\/<\/a><\/p>\n<p>There are no author submission or article processing fees.<\/p>\n<p>&nbsp;<\/p>\n<p>Follow <strong><em>Acta Materia Medica <\/em><\/strong>on Twitter <a href=\"https:\/\/twitter.com\/AMM_journal\">https:\/\/twitter.com\/AMM_journal<\/a>\u00a0 <a href=\"https:\/\/twitter.com\/ZoonosesJ\">https:\/\/twitter.com\/ZoonosesJ<\/a>; <a href=\"https:\/\/www.facebook.com\/Zoonoses-Journal-100462755574114\">Facebook<\/a> (<a href=\"https:\/\/www.facebook.com\/AMMjournal\">https:\/\/www.facebook.com\/AMMjournal<\/a>)<\/p>\n<p><strong>eISSN <\/strong>2737-7946<\/p>\n<p><strong># # # # # #<\/strong><\/p>\n<p>Bo Feng, Xiao Lu and Guangqin Zhang et al. STING agonist delivery by lipid calcium phosphate nanoparticles enhances immune activation for neuroblastoma.\u00a0<em>Acta Materia Medica.\u00a0<\/em>2023. Vol. 2(2):216-227. DOI: 10.15212\/AMM-2023-0011<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Announcing a new publication for Acta Materia Medica journal. \u00a0\u00a0Neuroblastoma (NB) is a common solid tumor in children and infants, the formation and regression of which is closely linked to the tumor-host immune relationship. Stimulator of interferon genes (STING) agonists, particularly cyclic dinucleotide (CDN), have promising potential in NB therapy by generating innate and adaptive [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2],"tags":[],"class_list":["post-834","post","type-post","status-publish","format-standard","hentry","category-news-and-events"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>STING agonist delivery by lipid calcium phosphate nanoparticles enhances immune activation for neuroblastoma - AMM Journal<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/amm-journal.org\/index.php\/2023\/07\/03\/sting-agonist-delivery-by-lipid-calcium-phosphate-nanoparticles-enhances-immune-activation-for-neuroblastoma\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"STING agonist delivery by lipid calcium phosphate nanoparticles enhances immune activation for neuroblastoma - AMM Journal\" \/>\n<meta property=\"og:description\" content=\"Announcing a new publication for Acta Materia Medica journal. \u00a0\u00a0Neuroblastoma (NB) is a common solid tumor in children and infants, the formation and regression of which is closely linked to the tumor-host immune relationship. 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