{"id":829,"date":"2023-07-03T09:33:53","date_gmt":"2023-07-03T09:33:53","guid":{"rendered":"https:\/\/amm-journal.org\/?p=829"},"modified":"2023-07-03T09:33:53","modified_gmt":"2023-07-03T09:33:53","slug":"biological-functions-and-therapeutic-potential-of-acylation-by-histone-acetyltransferases","status":"publish","type":"post","link":"https:\/\/amm-journal.org\/index.php\/2023\/07\/03\/biological-functions-and-therapeutic-potential-of-acylation-by-histone-acetyltransferases\/","title":{"rendered":"Biological functions and therapeutic potential of acylation by histone acetyltransferases"},"content":{"rendered":"

Announcing a new publication for Acta Materia Medica<\/em> journal. \u00a0\u00a0\u00a0Histone lysine acylation is a major class of histone post-translational modifications involved in essential biological activities, such as transcriptional regulation, DNA-damage repair, and cell-cycle progression. Abnormal acylation is strongly associated with various diseases, such as cancer. Thus, histone acetyltransferases (HATs), the \u201cwriters\u201d that catalyze histone acylation, are promising targets for cancer treatment. Rapid developments in structural biology and artificial intelligence have facilitated the development of drugs targeting HATs. To provide new ideas for exploring novel HAT modifiers with high efficiency and selectivity, this article reviews the relationships between acylation and diseases, illustrates HAT catalytic mechanisms through structural biology, and summarizes research progress in HAT modifiers.<\/p>\n

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Nan Li, Clark Hamor and Yahang An et al. Biological functions and therapeutic potential of acylation by histone acetyltransferases.\u00a0Acta Materia Medica.\u00a0<\/em>2023. Vol. 2(2):228-254. DOI: 10.15212\/AMM-2023-0010<\/p>\n","protected":false},"excerpt":{"rendered":"

Announcing a new publication for Acta Materia Medica journal. \u00a0\u00a0\u00a0Histone lysine acylation is a major class of histone post-translational modifications involved in essential biological activities, such as transcriptional regulation, DNA-damage repair, and cell-cycle progression. Abnormal acylation is strongly associated with various diseases, such as cancer. Thus, histone acetyltransferases (HATs), the \u201cwriters\u201d that catalyze histone acylation, […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2],"tags":[],"class_list":["post-829","post","type-post","status-publish","format-standard","hentry","category-news-and-events"],"yoast_head":"\nBiological functions and therapeutic potential of acylation by histone acetyltransferases - AMM Journal<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/amm-journal.org\/index.php\/2023\/07\/03\/biological-functions-and-therapeutic-potential-of-acylation-by-histone-acetyltransferases\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Biological functions and therapeutic potential of acylation by histone acetyltransferases - AMM Journal\" \/>\n<meta property=\"og:description\" content=\"Announcing a new publication for Acta Materia Medica journal. \u00a0\u00a0\u00a0Histone lysine acylation is a major class of histone post-translational modifications involved in essential biological activities, such as transcriptional regulation, DNA-damage repair, and cell-cycle progression. 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