{"id":824,"date":"2023-06-16T14:14:26","date_gmt":"2023-06-16T14:14:26","guid":{"rendered":"https:\/\/amm-journal.org\/?p=824"},"modified":"2023-06-16T14:14:33","modified_gmt":"2023-06-16T14:14:33","slug":"animal-models-of-alzheimers-disease-preclinical-insights-and-challenges","status":"publish","type":"post","link":"https:\/\/amm-journal.org\/index.php\/2023\/06\/16\/animal-models-of-alzheimers-disease-preclinical-insights-and-challenges\/","title":{"rendered":"Animal models of Alzheimer\u2019s disease: preclinical insights and challenges"},"content":{"rendered":"

Announcing a new publication for Acta Materia Medica<\/em> journal. \u00a0Alzheimer\u2019s disease (AD), an irreversible neurodegenerative disease that progressively impairs memory and cognitive judgment, severely affects the quality of life and imposes a heavy burden on the healthcare system. No cure is currently available for AD, in part because the pathogenesis of this disease has not been established. Animal models are essential for investigating AD pathogenesis and evaluating potential therapeutic strategies for AD. Some phenotypic and neuropathologic changes in AD patients can be recapitulated with genetic and pharmacologic approaches in animals. This article systematically reviews the animal models available for AD research, including transgenic, chemical- or drug-induced, and spontaneous animal models, and the characteristics of these animal models. In this review we also discuss the challenges and constraints when using AD animal models. Although no single animal model can reproduce all pathologic aspects and behavioral features in AD patients, the currently available AD models are valuable tools for deciphering the pathogenic mechanisms underlying AD and developing new anti-AD therapeutics.<\/p>\n

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eISSN <\/strong>2737-7946<\/p>\n

Qing-Qing Xu, Wen Yang and Mei Zhong et al. Animal models of Alzheimer\u2019s disease: preclinical insights and challenges.\u00a0Acta Materia Medica.\u00a0<\/em>2023. Vol. 2(2):192-215. DOI: 10.15212\/AMM-2023-0001<\/p>\n","protected":false},"excerpt":{"rendered":"

Announcing a new publication for Acta Materia Medica journal. \u00a0Alzheimer\u2019s disease (AD), an irreversible neurodegenerative disease that progressively impairs memory and cognitive judgment, severely affects the quality of life and imposes a heavy burden on the healthcare system. No cure is currently available for AD, in part because the pathogenesis of this disease has not […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2],"tags":[201,17,202,181],"class_list":["post-824","post","type-post","status-publish","format-standard","hentry","category-news-and-events","tag-ad","tag-alzheimers-disease","tag-healthcare-systems","tag-research"],"yoast_head":"\nAnimal models of Alzheimer\u2019s disease: preclinical insights and challenges - AMM Journal<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/amm-journal.org\/index.php\/2023\/06\/16\/animal-models-of-alzheimers-disease-preclinical-insights-and-challenges\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Animal models of Alzheimer\u2019s disease: preclinical insights and challenges - AMM Journal\" \/>\n<meta property=\"og:description\" content=\"Announcing a new publication for Acta Materia Medica journal. \u00a0Alzheimer\u2019s disease (AD), an irreversible neurodegenerative disease that progressively impairs memory and cognitive judgment, severely affects the quality of life and imposes a heavy burden on the healthcare system. 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