{"id":798,"date":"2023-05-08T10:32:51","date_gmt":"2023-05-08T10:32:51","guid":{"rendered":"https:\/\/amm-journal.org\/?p=798"},"modified":"2023-05-08T10:32:51","modified_gmt":"2023-05-08T10:32:51","slug":"emerging-role-of-hjurp-as-a-therapeutic-target-in-cancers","status":"publish","type":"post","link":"https:\/\/amm-journal.org\/index.php\/2023\/05\/08\/emerging-role-of-hjurp-as-a-therapeutic-target-in-cancers\/","title":{"rendered":"Emerging role of HJURP as a therapeutic target in cancers"},"content":{"rendered":"

Announcing a new publication for Acta Materia Medica<\/em> journal.<\/p>\n

Holliday junction recognition protein (HJURP) is a key molecular chaperone for centromere protein A (CENP-A), which is essential for chromosome separation during mitosis and cell cycle regulation. Recent studies have identified the essential role of HJURP in carcinogenesis. Abnormal upregulation of HJURP expression has been observed in various human cancers, such as non-small cell lung cancer (NSCLC), hepatocellular carcinoma (HCC), bladder cancer, and breast cancer, and is associated with poor pathologic development and prognosis.\u00a0In vitro<\/em>\u00a0and\u00a0in vivo<\/em>\u00a0studies have shown that HJURP mainly exerts oncogenic functions by regulating the cell cycle, cellular senescence, and epithelial-mesenchymal transition (EMT).<\/p>\n

This article evaluates the prognostic significance of HJURP in human cancers and summarize anti-tumor studies targeting HJURP. The factors regulating HJURP in carcinogenesis and the corresponding effects are also discussed to provide new insight into targeting HJURP as a promising strategy for cancer treatment.<\/p>\n

https:\/\/www.scienceopen.com\/hosted-document?doi=10.15212\/AMM-2023-0008<\/p>\n

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eISSN <\/strong>2737-7946<\/p>\n

Jiaqi Tan, Lertnimitphun Peeraphong and Chattarin Ruchawapol et al. Emerging role of HJURP as a therapeutic target in cancers.\u00a0Acta Materia Medica.\u00a0<\/em>2023. Vol. 2(2):157-171. DOI: 10.15212\/AMM-2023-0008<\/p>\n","protected":false},"excerpt":{"rendered":"

Announcing a new publication for Acta Materia Medica journal. Holliday junction recognition protein (HJURP) is a key molecular chaperone for centromere protein A (CENP-A), which is essential for chromosome separation during mitosis and cell cycle regulation. Recent studies have identified the essential role of HJURP in carcinogenesis. Abnormal upregulation of HJURP expression has been observed […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2],"tags":[187,188],"class_list":["post-798","post","type-post","status-publish","format-standard","hentry","category-news-and-events","tag-cancer","tag-chromosome-separation"],"yoast_head":"\nEmerging role of HJURP as a therapeutic target in cancers - AMM Journal<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/amm-journal.org\/index.php\/2023\/05\/08\/emerging-role-of-hjurp-as-a-therapeutic-target-in-cancers\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Emerging role of HJURP as a therapeutic target in cancers - AMM Journal\" \/>\n<meta property=\"og:description\" content=\"Announcing a new publication for Acta Materia Medica journal. 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