{"id":796,"date":"2023-05-02T14:40:15","date_gmt":"2023-05-02T14:40:15","guid":{"rendered":"https:\/\/amm-journal.org\/?p=796"},"modified":"2023-05-02T14:40:15","modified_gmt":"2023-05-02T14:40:15","slug":"inhalable-ciprofloxacin-polymyxin-b-dry-powders-in-respiratory-infection-therapy","status":"publish","type":"post","link":"https:\/\/amm-journal.org\/index.php\/2023\/05\/02\/inhalable-ciprofloxacin-polymyxin-b-dry-powders-in-respiratory-infection-therapy\/","title":{"rendered":"Inhalable ciprofloxacin\/polymyxin B dry powders in respiratory infection therapy"},"content":{"rendered":"

Announcing a new publication for Acta Materia Medica<\/em> journal. \u00a0This study focuses on the formulation, physicochemical characterization, and antibacterial susceptibility testing of inhalable spray dried powders containing ciprofloxacin (CIP) and polymyxin B sulfate (PMB).<\/p>\n

CIP nanosuspensions with an average particle diameter of 435.9 \u00b1 9.3 nm were initially obtained using the wet-milling protocol and subsequently co-spray dried with PMB solutions to yield inhalable dry powders. The Powder X-Ray Diffraction (P-XRD) results showed that the wet-milled CIP nanoparticles were in a 4.8 hydrate state, which were transformed to 3.7 hydrates and amorphous materials after co-spray drying. The PMB remained in an amorphous state in the dry powders. Differential Scanning Calorimetry (DSC) analyses revealed that the glass transition temperatures (Tg<\/sub>s) of the co\u2013spray dried formulations were higher than the Tg<\/sub>\u00a0of CIP, but lower than the Tg<\/sub>\u00a0of PMB. Fourier Transform Infrared Spectrometer (FTIR) studies suggested the existence of \u03c0 – \u03c0 interactions between CIP and PMB in the co-spray dried powders. These powders also retained antimicrobial effects against\u00a0Pseudomonas aeruginosa<\/em>\u00a0strain PAO1. In addition, the spray-dried powder formulations exhibited satisfactory solid-state stability and aerodynamic characteristics when stored under 3% relative humidity and 20 \u00b1 5 \u00b0C for 4 months.<\/p>\n

Overall, the newly developed inhalable CIP\/PMB dry powders are a promising therapeutic strategy for respiratory tract infections.<\/p>\n

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eISSN <\/strong>2737-7946<\/p>\n

Zhengqi Xu, Hriday Bera and Hengzhuang Wang et al. Inhalable ciprofloxacin\/polymyxin B dry powders in respiratory infection therapy.\u00a0Acta Materia Medica.\u00a0<\/em>2023. Vol. 2(2):142-156. DOI: 10.15212\/AMM-2022-0050<\/p>\n","protected":false},"excerpt":{"rendered":"

Announcing a new publication for Acta Materia Medica journal. \u00a0This study focuses on the formulation, physicochemical characterization, and antibacterial susceptibility testing of inhalable spray dried powders containing ciprofloxacin (CIP) and polymyxin B sulfate (PMB). CIP nanosuspensions with an average particle diameter of 435.9 \u00b1 9.3 nm were initially obtained using the wet-milling protocol and subsequently […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2],"tags":[184,183,185,186],"class_list":["post-796","post","type-post","status-publish","format-standard","hentry","category-news-and-events","tag-cip","tag-ciprofloxacin","tag-polymyxin-b-sulfate","tag-respiratory-infection"],"yoast_head":"\nInhalable ciprofloxacin\/polymyxin B dry powders in respiratory infection therapy - AMM Journal<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/amm-journal.org\/index.php\/2023\/05\/02\/inhalable-ciprofloxacin-polymyxin-b-dry-powders-in-respiratory-infection-therapy\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Inhalable ciprofloxacin\/polymyxin B dry powders in respiratory infection therapy - AMM Journal\" \/>\n<meta property=\"og:description\" content=\"Announcing a new publication for Acta Materia Medica journal. \u00a0This study focuses on the formulation, physicochemical characterization, and antibacterial susceptibility testing of inhalable spray dried powders containing ciprofloxacin (CIP) and polymyxin B sulfate (PMB). 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