{"id":525,"date":"2023-01-04T09:29:06","date_gmt":"2023-01-04T09:29:06","guid":{"rendered":"https:\/\/amm-journal.org\/?p=525"},"modified":"2023-01-04T09:29:06","modified_gmt":"2023-01-04T09:29:06","slug":"mass-spectrometry-imaging-advances-and-application-in-pharmaceutical-research","status":"publish","type":"post","link":"https:\/\/amm-journal.org\/index.php\/2023\/01\/04\/mass-spectrometry-imaging-advances-and-application-in-pharmaceutical-research\/","title":{"rendered":"Mass spectrometry imaging advances and application in pharmaceutical research"},"content":{"rendered":"

Announcing a new publication for Acta Materia Medica<\/em> journal. Mass spectrometry imaging (MSI) has been shown to be a valuable tool through nearly every stage of the preclinical drug research and development (R&D) pipeline, and even to the early phase of clinical pharmaceutical evaluation. MSI can specifically resolve distributions of a parent drug and its metabolic products across dosed specimens without loss of spatial information, thus facilitating the direct observation of a drug\u2019s pharmacokinetic processes, such as absorption, distribution, metabolism, and excretion. MSI can simultaneously visualize hundreds of phenotype molecules, including proteins, glycans, metabolites, and lipids, which have unique distribution patterns and biofunctions across different physiologic regions. This featured specificity in the chemical and physical spaces empowers MSI as an ideal analytical technique in exploring a drug\u2019s pharmacodynamic properties, including\u00a0in vitro\/in vivo<\/em>\u00a0efficacy, safety, potential toxicity, and possible molecular mechanism. The application of MSI in pharmaceutical research has also been expanded from the conventional dosed tissue analysis to the front end of the preclinical drug R&D pipeline, such as investigating the structure-activity relationship, high-throughput\u00a0in vitro<\/em>\u00a0screening, and\u00a0ex vivo<\/em>\u00a0studies on single cells, organoids, or tumor spheroids. This article summarizes MSI application in pharmaceutical research accompanied by its technical and methodologic advances serving this central demand.<\/p>\n

https:\/\/www.scienceopen.com\/hosted-document?doi=10.15212\/AMM-2022-0046<\/a><\/p>\n

Keywords:<\/strong> mass spectrometry imaging, drug metabolism and pharmacokinetics, toxicology, in vitro efficacy evaluation , pharmaceutical research and development<\/p>\n

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eISSN <\/strong>2737-7946<\/p>\n

Article Reference:<\/strong> Xiaowei Song, Chao Li and Yifan Meng. Mass spectrometry imaging advances and application in pharmaceutical research.\u00a0Acta Materia Medica.\u00a0<\/em>Vol. 1(4):507-533. DOI: 10.15212\/AMM-2022-0046<\/p>\n","protected":false},"excerpt":{"rendered":"

Announcing a new publication for Acta Materia Medica journal. Mass spectrometry imaging (MSI) has been shown to be a valuable tool through nearly every stage of the preclinical drug research and development (R&D) pipeline, and even to the early phase of clinical pharmaceutical evaluation. MSI can specifically resolve distributions of a parent drug and its […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2],"tags":[141,143,140,144,142],"class_list":["post-525","post","type-post","status-publish","format-standard","hentry","category-news-and-events","tag-drug-metabolism-and-pharmacokinetics","tag-in-vitro-efficacy-evaluation","tag-mass-spectrometry-imaging","tag-pharmaceutical-research-and-development","tag-toxicology"],"yoast_head":"\nMass spectrometry imaging advances and application in pharmaceutical research - AMM Journal<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/amm-journal.org\/index.php\/2023\/01\/04\/mass-spectrometry-imaging-advances-and-application-in-pharmaceutical-research\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Mass spectrometry imaging advances and application in pharmaceutical research - AMM Journal\" \/>\n<meta property=\"og:description\" content=\"Announcing a new publication for Acta Materia Medica journal. 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