{"id":504,"date":"2022-11-16T11:14:38","date_gmt":"2022-11-16T11:14:38","guid":{"rendered":"https:\/\/amm-journal.org\/?p=504"},"modified":"2022-11-16T11:14:53","modified_gmt":"2022-11-16T11:14:53","slug":"biothiol-triggered-h2s-release-from-a-near-infrared-fluorescent-h2s-donor-promotes-cutaneous-wound-healing","status":"publish","type":"post","link":"https:\/\/amm-journal.org\/index.php\/2022\/11\/16\/biothiol-triggered-h2s-release-from-a-near-infrared-fluorescent-h2s-donor-promotes-cutaneous-wound-healing\/","title":{"rendered":"Biothiol-triggered H2S release from a near-infrared fluorescent H2S donor promotes cutaneous wound healing"},"content":{"rendered":"

Announcing a new publication for Acta Materia Medica<\/em> journal. \u00a0\u00a0\u00a0Hydrogen sulfide (H2<\/sub>S) plays crucial roles in antioxidation, anti-inflammation, and cytoprotection. Despite substantial progress in the design and synthesis of activatable H2<\/sub>S donors, methods for high-precision detection and imaging of released H2<\/sub>S in living systems have been lacking. In this study, a biothiol-activated near-infrared (NIR) fluorescent H2<\/sub>S donor,\u00a0PRO-ST<\/strong>, was developed for real-time visualization of H2<\/sub>S release.\u00a0PRO-ST<\/strong>\u00a0consists of a dicyanoisophorone-based NIR fluorescence moiety (TCOO), a biothiol-trigger moiety (4-isothiocyanate benzyl alcohol), and a sulfur-source group (thiophosgene).\u00a0PRO-ST<\/strong>\u00a0exhibits high NIR fluorescence enhancement (45-fold), outstanding H2<\/sub>S release efficiency (73%), controllable H2<\/sub>S release (60 min), and excellent cell compatibility. These distinctive features enable\u00a0PRO-ST<\/strong>\u00a0to be applied in visualizing H2<\/sub>S release in cells, zebrafish, and mice. Moreover,\u00a0PRO-ST<\/strong>\u00a0exhibits excellent performance in visualizing real-time anti-inflammation and wound healing enhancement in biological systems, as confirmed by\u00a0in situ<\/em>\u00a0visualization of H2<\/sub>S release. Thus,\u00a0PRO-ST<\/strong>\u00a0provides a versatile and effective method to detect and visualize H2<\/sub>S release, elucidate the mechanisms underlying wound healing, or optimize interventional therapy.<\/p>\n

https:\/\/www.scienceopen.com\/hosted-document?doi=10.15212\/AMM-2022-0032<\/a><\/p>\n

Keywords:<\/strong> H2<\/sub>S donor, Biothiol-activated, Anti-inflammatory, Wound healing<\/p>\n

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eISSN <\/strong>2737-7946<\/p>\n

Article Reference:<\/strong> Xinyue Zhao, Mengbin Ding and Lulu Ning et al. Biothiol-triggered H2<\/sub>S release from a near-infrared fluorescent H2<\/sub>S donor promotes cutaneous wound healing.\u00a0Acta Materia Medica.\u00a0<\/em>Vol. 1(4):476-485. DOI: 10.15212\/AMM-2022-0032<\/p>\n","protected":false},"excerpt":{"rendered":"

Announcing a new publication for Acta Materia Medica journal. \u00a0\u00a0\u00a0Hydrogen sulfide (H2S) plays crucial roles in antioxidation, anti-inflammation, and cytoprotection. Despite substantial progress in the design and synthesis of activatable H2S donors, methods for high-precision detection and imaging of released H2S in living systems have been lacking. In this study, a biothiol-activated near-infrared (NIR) fluorescent […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2],"tags":[130,129,128,131],"class_list":["post-504","post","type-post","status-publish","format-standard","hentry","category-news-and-events","tag-anti-inflammatory","tag-biothiol-activated","tag-h2s-donor","tag-wound-healing"],"yoast_head":"\nBiothiol-triggered H2S release from a near-infrared fluorescent H2S donor promotes cutaneous wound healing - AMM Journal<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/amm-journal.org\/index.php\/2022\/11\/16\/biothiol-triggered-h2s-release-from-a-near-infrared-fluorescent-h2s-donor-promotes-cutaneous-wound-healing\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Biothiol-triggered H2S release from a near-infrared fluorescent H2S donor promotes cutaneous wound healing - AMM Journal\" \/>\n<meta property=\"og:description\" content=\"Announcing a new publication for Acta Materia Medica journal. \u00a0\u00a0\u00a0Hydrogen sulfide (H2S) plays crucial roles in antioxidation, anti-inflammation, and cytoprotection. 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