{"id":418,"date":"2022-10-10T10:37:11","date_gmt":"2022-10-10T10:37:11","guid":{"rendered":"https:\/\/amm-journal.org\/?p=418"},"modified":"2022-10-10T10:37:55","modified_gmt":"2022-10-10T10:37:55","slug":"protective-effects-of-ginsenoside-ck-against-oxidative-stress-induced-neuronal-damage-assessed-with-1h-nmr-based-metabolomics","status":"publish","type":"post","link":"https:\/\/amm-journal.org\/index.php\/2022\/10\/10\/protective-effects-of-ginsenoside-ck-against-oxidative-stress-induced-neuronal-damage-assessed-with-1h-nmr-based-metabolomics\/","title":{"rendered":"Protective effects of ginsenoside CK against oxidative stress-induced neuronal damage, assessed with 1H-NMR-based metabolomics"},"content":{"rendered":"<p>Announcing a new publication for<em> Acta Materia Medica<\/em> journal. Oxidative stress is an important pathogenic mechanism in degenerative diseases such as Alzheimer\u2019s disease. Although ginsenoside compound K (CK) is protective against neuronal oxidative damage, the underlying mechanism remains to be understood. In this article, the protective effects of ginsenoside CK against oxidative stress damage induced by hydrogen peroxide in HT22 cells were investigated with\u00a0<sup>1<\/sup>H nuclear magnetic resonance (<sup>1<\/sup>H-NMR)-based metabolomics. The optimal CK concentration for decreasing oxidative stress damage in nerves was determined with MTT assays. CK (8 \u03bcM) significantly increased the HT22 cell survival rate after the model was established. Cell lysates were subjected to\u00a0<sup>1<\/sup>H-NMR metabolomics, western blotting, and ATP assays for verification. Metabolic perturbation occurred in HT22 cells in the model group but not the control group. Twenty biomarkers were identified and used to analyze metabolic pathways. CK reversed metabolic changes in HT22 cells by altering taurine, glutamate, glycine, and glutathione metabolism. Subsequently, CK increased ATP content and the expression of components of the PI3K\/AKT signaling pathway in HT22 cells. These findings demonstrate that CK prevents oxidative stress damage and protects nerves by regulating energy-metabolism pathways, such as those of taurine, glutamate, and other amino acids, thus providing a rationale for the use of CK in Alzheimer\u2019s disease treatment.<\/p>\n<p><a href=\"https:\/\/www.scienceopen.com\/hosted-document?doi=10.15212\/AMM-2022-0009\">https:\/\/www.scienceopen.com\/hosted-document?doi=10.15212\/AMM-2022-0009<\/a><\/p>\n<p><strong>Article Reference:<\/strong> Na Li, Yanhong Zhang and Jingwei Lv et al. Protective effects of ginsenoside CK against oxidative stress-induced neuronal damage, assessed with 1H-NMR-based metabolomics.\u00a0<em>Acta Materia Medica.\u00a0<\/em>Vol. 1(3):392-399. DOI: 10.15212\/AMM-2022-0009<\/p>\n<p><strong>Keywords:<\/strong> oxidative stress, ginsenoside CK, metabolomics, ATP<\/p>\n<p><em>Acta Materia Medica<\/em> welcomes the submission of research articles, review articles, databases, mini reviews, commentaries, editorials, short communications, case report articles and study protocols.<\/p>\n<p><strong>Submission Process<\/strong><\/p>\n<p>Submissions <em>to Acta Materia Medica<\/em> are made using ScholarOne, the online submission and peer review system. Registration and access are available at <a href=\"https:\/\/mc04.manuscriptcentral.com\/ammed\">https:\/\/mc04.manuscriptcentral.com\/ammed<\/a><\/p>\n<p>Queries about the journal can be sent to editorialoffice@amm-journal.org.<\/p>\n<p>Please visit <a href=\"https:\/\/amm-journal.org\/\">https:\/\/amm-journal.org\/<\/a> to learn more about the journal.<\/p>\n<p><strong>Editorial Board:<\/strong> <a href=\"https:\/\/amm-journal.org\/index.php\/editorial-board\/\">https:\/\/amm-journal.org\/index.php\/editorial-board\/<\/a><\/p>\n<p>There are no author submission or article processing fees.<\/p>\n<p>Follow <strong><em>Acta Materia Medica <\/em><\/strong>on Twitter <a href=\"https:\/\/twitter.com\/AMM_journal\">https:\/\/twitter.com\/AMM_journal<\/a>\u00a0 <a href=\"https:\/\/twitter.com\/ZoonosesJ\">https:\/\/twitter.com\/ZoonosesJ<\/a>; <a href=\"https:\/\/www.facebook.com\/Zoonoses-Journal-100462755574114\">Facebook<\/a> (<a href=\"https:\/\/www.facebook.com\/AMMjournal\">https:\/\/www.facebook.com\/AMMjournal<\/a>)<\/p>\n<p><strong>eISSN <\/strong>2737-7946<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Announcing a new publication for Acta Materia Medica journal. Oxidative stress is an important pathogenic mechanism in degenerative diseases such as Alzheimer\u2019s disease. Although ginsenoside compound K (CK) is protective against neuronal oxidative damage, the underlying mechanism remains to be understood. In this article, the protective effects of ginsenoside CK against oxidative stress damage induced [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2],"tags":[113,111,112,110],"class_list":["post-418","post","type-post","status-publish","format-standard","hentry","category-news-and-events","tag-atp","tag-ginsenoside-ck","tag-metabolomics","tag-oxidative-stress"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Protective effects of ginsenoside CK against oxidative stress-induced neuronal damage, assessed with 1H-NMR-based metabolomics - AMM Journal<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/amm-journal.org\/index.php\/2022\/10\/10\/protective-effects-of-ginsenoside-ck-against-oxidative-stress-induced-neuronal-damage-assessed-with-1h-nmr-based-metabolomics\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Protective effects of ginsenoside CK against oxidative stress-induced neuronal damage, assessed with 1H-NMR-based metabolomics - AMM Journal\" \/>\n<meta property=\"og:description\" content=\"Announcing a new publication for Acta Materia Medica journal. Oxidative stress is an important pathogenic mechanism in degenerative diseases such as Alzheimer\u2019s disease. Although ginsenoside compound K (CK) is protective against neuronal oxidative damage, the underlying mechanism remains to be understood. In this article, the protective effects of ginsenoside CK against oxidative stress damage induced [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/amm-journal.org\/index.php\/2022\/10\/10\/protective-effects-of-ginsenoside-ck-against-oxidative-stress-induced-neuronal-damage-assessed-with-1h-nmr-based-metabolomics\/\" \/>\n<meta property=\"og:site_name\" content=\"AMM Journal\" \/>\n<meta property=\"article:published_time\" content=\"2022-10-10T10:37:11+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2022-10-10T10:37:55+00:00\" \/>\n<meta name=\"author\" content=\"Compuscript\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Compuscript\" \/>\n\t<meta name=\"twitter:label2\" content=\"Estimated reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/amm-journal.org\\\/index.php\\\/2022\\\/10\\\/10\\\/protective-effects-of-ginsenoside-ck-against-oxidative-stress-induced-neuronal-damage-assessed-with-1h-nmr-based-metabolomics\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/amm-journal.org\\\/index.php\\\/2022\\\/10\\\/10\\\/protective-effects-of-ginsenoside-ck-against-oxidative-stress-induced-neuronal-damage-assessed-with-1h-nmr-based-metabolomics\\\/\"},\"author\":{\"name\":\"Compuscript\",\"@id\":\"https:\\\/\\\/amm-journal.org\\\/#\\\/schema\\\/person\\\/0935dba5c919585e39f756ce09930a67\"},\"headline\":\"Protective effects of ginsenoside CK against oxidative stress-induced neuronal damage, assessed with 1H-NMR-based metabolomics\",\"datePublished\":\"2022-10-10T10:37:11+00:00\",\"dateModified\":\"2022-10-10T10:37:55+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/amm-journal.org\\\/index.php\\\/2022\\\/10\\\/10\\\/protective-effects-of-ginsenoside-ck-against-oxidative-stress-induced-neuronal-damage-assessed-with-1h-nmr-based-metabolomics\\\/\"},\"wordCount\":393,\"commentCount\":0,\"keywords\":[\"ATP\",\"ginsenoside CK\",\"metabolomics\",\"oxidative stress\"],\"articleSection\":[\"News and Events\"],\"inLanguage\":\"en-GB\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\\\/\\\/amm-journal.org\\\/index.php\\\/2022\\\/10\\\/10\\\/protective-effects-of-ginsenoside-ck-against-oxidative-stress-induced-neuronal-damage-assessed-with-1h-nmr-based-metabolomics\\\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/amm-journal.org\\\/index.php\\\/2022\\\/10\\\/10\\\/protective-effects-of-ginsenoside-ck-against-oxidative-stress-induced-neuronal-damage-assessed-with-1h-nmr-based-metabolomics\\\/\",\"url\":\"https:\\\/\\\/amm-journal.org\\\/index.php\\\/2022\\\/10\\\/10\\\/protective-effects-of-ginsenoside-ck-against-oxidative-stress-induced-neuronal-damage-assessed-with-1h-nmr-based-metabolomics\\\/\",\"name\":\"Protective effects of ginsenoside CK against oxidative stress-induced neuronal damage, assessed with 1H-NMR-based metabolomics - AMM Journal\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/amm-journal.org\\\/#website\"},\"datePublished\":\"2022-10-10T10:37:11+00:00\",\"dateModified\":\"2022-10-10T10:37:55+00:00\",\"author\":{\"@id\":\"https:\\\/\\\/amm-journal.org\\\/#\\\/schema\\\/person\\\/0935dba5c919585e39f756ce09930a67\"},\"breadcrumb\":{\"@id\":\"https:\\\/\\\/amm-journal.org\\\/index.php\\\/2022\\\/10\\\/10\\\/protective-effects-of-ginsenoside-ck-against-oxidative-stress-induced-neuronal-damage-assessed-with-1h-nmr-based-metabolomics\\\/#breadcrumb\"},\"inLanguage\":\"en-GB\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/amm-journal.org\\\/index.php\\\/2022\\\/10\\\/10\\\/protective-effects-of-ginsenoside-ck-against-oxidative-stress-induced-neuronal-damage-assessed-with-1h-nmr-based-metabolomics\\\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/amm-journal.org\\\/index.php\\\/2022\\\/10\\\/10\\\/protective-effects-of-ginsenoside-ck-against-oxidative-stress-induced-neuronal-damage-assessed-with-1h-nmr-based-metabolomics\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/amm-journal.org\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Protective effects of ginsenoside CK against oxidative stress-induced neuronal damage, assessed with 1H-NMR-based metabolomics\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/amm-journal.org\\\/#website\",\"url\":\"https:\\\/\\\/amm-journal.org\\\/\",\"name\":\"AMM Journal\",\"description\":\"\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/amm-journal.org\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-GB\"},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/amm-journal.org\\\/#\\\/schema\\\/person\\\/0935dba5c919585e39f756ce09930a67\",\"name\":\"Compuscript\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-GB\",\"@id\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/fb3d42af3c1b48f4d76adf5524c6c3447a369d2a7bcb666ef995240441912a6b?s=96&d=mm&r=g\",\"url\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/fb3d42af3c1b48f4d76adf5524c6c3447a369d2a7bcb666ef995240441912a6b?s=96&d=mm&r=g\",\"contentUrl\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/fb3d42af3c1b48f4d76adf5524c6c3447a369d2a7bcb666ef995240441912a6b?s=96&d=mm&r=g\",\"caption\":\"Compuscript\"},\"sameAs\":[\"https:\\\/\\\/amm-journal.org\"],\"url\":\"https:\\\/\\\/amm-journal.org\\\/index.php\\\/author\\\/ammjadmin\\\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Protective effects of ginsenoside CK against oxidative stress-induced neuronal damage, assessed with 1H-NMR-based metabolomics - AMM Journal","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/amm-journal.org\/index.php\/2022\/10\/10\/protective-effects-of-ginsenoside-ck-against-oxidative-stress-induced-neuronal-damage-assessed-with-1h-nmr-based-metabolomics\/","og_locale":"en_GB","og_type":"article","og_title":"Protective effects of ginsenoside CK against oxidative stress-induced neuronal damage, assessed with 1H-NMR-based metabolomics - AMM Journal","og_description":"Announcing a new publication for Acta Materia Medica journal. Oxidative stress is an important pathogenic mechanism in degenerative diseases such as Alzheimer\u2019s disease. Although ginsenoside compound K (CK) is protective against neuronal oxidative damage, the underlying mechanism remains to be understood. In this article, the protective effects of ginsenoside CK against oxidative stress damage induced [&hellip;]","og_url":"https:\/\/amm-journal.org\/index.php\/2022\/10\/10\/protective-effects-of-ginsenoside-ck-against-oxidative-stress-induced-neuronal-damage-assessed-with-1h-nmr-based-metabolomics\/","og_site_name":"AMM Journal","article_published_time":"2022-10-10T10:37:11+00:00","article_modified_time":"2022-10-10T10:37:55+00:00","author":"Compuscript","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Compuscript","Estimated reading time":"2 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/amm-journal.org\/index.php\/2022\/10\/10\/protective-effects-of-ginsenoside-ck-against-oxidative-stress-induced-neuronal-damage-assessed-with-1h-nmr-based-metabolomics\/#article","isPartOf":{"@id":"https:\/\/amm-journal.org\/index.php\/2022\/10\/10\/protective-effects-of-ginsenoside-ck-against-oxidative-stress-induced-neuronal-damage-assessed-with-1h-nmr-based-metabolomics\/"},"author":{"name":"Compuscript","@id":"https:\/\/amm-journal.org\/#\/schema\/person\/0935dba5c919585e39f756ce09930a67"},"headline":"Protective effects of ginsenoside CK against oxidative stress-induced neuronal damage, assessed with 1H-NMR-based metabolomics","datePublished":"2022-10-10T10:37:11+00:00","dateModified":"2022-10-10T10:37:55+00:00","mainEntityOfPage":{"@id":"https:\/\/amm-journal.org\/index.php\/2022\/10\/10\/protective-effects-of-ginsenoside-ck-against-oxidative-stress-induced-neuronal-damage-assessed-with-1h-nmr-based-metabolomics\/"},"wordCount":393,"commentCount":0,"keywords":["ATP","ginsenoside CK","metabolomics","oxidative stress"],"articleSection":["News and Events"],"inLanguage":"en-GB","potentialAction":[{"@type":"CommentAction","name":"Comment","target":["https:\/\/amm-journal.org\/index.php\/2022\/10\/10\/protective-effects-of-ginsenoside-ck-against-oxidative-stress-induced-neuronal-damage-assessed-with-1h-nmr-based-metabolomics\/#respond"]}]},{"@type":"WebPage","@id":"https:\/\/amm-journal.org\/index.php\/2022\/10\/10\/protective-effects-of-ginsenoside-ck-against-oxidative-stress-induced-neuronal-damage-assessed-with-1h-nmr-based-metabolomics\/","url":"https:\/\/amm-journal.org\/index.php\/2022\/10\/10\/protective-effects-of-ginsenoside-ck-against-oxidative-stress-induced-neuronal-damage-assessed-with-1h-nmr-based-metabolomics\/","name":"Protective effects of ginsenoside CK against oxidative stress-induced neuronal damage, assessed with 1H-NMR-based metabolomics - AMM Journal","isPartOf":{"@id":"https:\/\/amm-journal.org\/#website"},"datePublished":"2022-10-10T10:37:11+00:00","dateModified":"2022-10-10T10:37:55+00:00","author":{"@id":"https:\/\/amm-journal.org\/#\/schema\/person\/0935dba5c919585e39f756ce09930a67"},"breadcrumb":{"@id":"https:\/\/amm-journal.org\/index.php\/2022\/10\/10\/protective-effects-of-ginsenoside-ck-against-oxidative-stress-induced-neuronal-damage-assessed-with-1h-nmr-based-metabolomics\/#breadcrumb"},"inLanguage":"en-GB","potentialAction":[{"@type":"ReadAction","target":["https:\/\/amm-journal.org\/index.php\/2022\/10\/10\/protective-effects-of-ginsenoside-ck-against-oxidative-stress-induced-neuronal-damage-assessed-with-1h-nmr-based-metabolomics\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/amm-journal.org\/index.php\/2022\/10\/10\/protective-effects-of-ginsenoside-ck-against-oxidative-stress-induced-neuronal-damage-assessed-with-1h-nmr-based-metabolomics\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/amm-journal.org\/"},{"@type":"ListItem","position":2,"name":"Protective effects of ginsenoside CK against oxidative stress-induced neuronal damage, assessed with 1H-NMR-based metabolomics"}]},{"@type":"WebSite","@id":"https:\/\/amm-journal.org\/#website","url":"https:\/\/amm-journal.org\/","name":"AMM Journal","description":"","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/amm-journal.org\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-GB"},{"@type":"Person","@id":"https:\/\/amm-journal.org\/#\/schema\/person\/0935dba5c919585e39f756ce09930a67","name":"Compuscript","image":{"@type":"ImageObject","inLanguage":"en-GB","@id":"https:\/\/secure.gravatar.com\/avatar\/fb3d42af3c1b48f4d76adf5524c6c3447a369d2a7bcb666ef995240441912a6b?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/fb3d42af3c1b48f4d76adf5524c6c3447a369d2a7bcb666ef995240441912a6b?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/fb3d42af3c1b48f4d76adf5524c6c3447a369d2a7bcb666ef995240441912a6b?s=96&d=mm&r=g","caption":"Compuscript"},"sameAs":["https:\/\/amm-journal.org"],"url":"https:\/\/amm-journal.org\/index.php\/author\/ammjadmin\/"}]}},"_links":{"self":[{"href":"https:\/\/amm-journal.org\/index.php\/wp-json\/wp\/v2\/posts\/418","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/amm-journal.org\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/amm-journal.org\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/amm-journal.org\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/amm-journal.org\/index.php\/wp-json\/wp\/v2\/comments?post=418"}],"version-history":[{"count":2,"href":"https:\/\/amm-journal.org\/index.php\/wp-json\/wp\/v2\/posts\/418\/revisions"}],"predecessor-version":[{"id":420,"href":"https:\/\/amm-journal.org\/index.php\/wp-json\/wp\/v2\/posts\/418\/revisions\/420"}],"wp:attachment":[{"href":"https:\/\/amm-journal.org\/index.php\/wp-json\/wp\/v2\/media?parent=418"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/amm-journal.org\/index.php\/wp-json\/wp\/v2\/categories?post=418"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/amm-journal.org\/index.php\/wp-json\/wp\/v2\/tags?post=418"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}