{"id":376,"date":"2022-08-04T08:14:00","date_gmt":"2022-08-04T08:14:00","guid":{"rendered":"https:\/\/amm-journal.org\/?p=376"},"modified":"2022-08-04T08:16:33","modified_gmt":"2022-08-04T08:16:33","slug":"silybin-has-therapeutic-efficacy-against-non-small-cell-lung-cancer-through-targeting-of-skp2","status":"publish","type":"post","link":"https:\/\/amm-journal.org\/index.php\/2022\/08\/04\/silybin-has-therapeutic-efficacy-against-non-small-cell-lung-cancer-through-targeting-of-skp2\/","title":{"rendered":"Silybin has therapeutic efficacy against non-small cell lung cancer through targeting of Skp2"},"content":{"rendered":"

Announcing a new review article publication for Acta Materia Medica<\/em> journal. Silybin (SB), a natural flavonoid isolated from\u00a0Silybum marianum<\/em>, has been used to treat hepatic fibrosis in clinical settings and as a dietary supplement, because of its hepatoprotective potential. Numerous studies have shown that SB also exerts promising anticancer effects; however, the anticancer targets of SB and the underlying mechanism were unclear. The authors of this article found that SB significantly inhibited the proliferation of non-small cell lung cancer without causing cytotoxicity toward normal Beas-2B bronchial epithelial cells. Mechanistically, SB binds the F-box protein Skp2 and disrupts Skp1-Skp2 interaction, thereby decreasing Skp2 protein levels, inducing accumulation of Skp2 substrates, and leading to G1-phase cell-cycle arrest and the suppression of cell migration. In lung orthotopic xenografts, SB also significantly decreased Skp2 expression and increased p27\/Kip1 protein levels. SB administration inhibited tumor growth and metastasis in lung tissue, thus prolonging survival time in mice without causing obvious toxicity. Thus, SB is a potential Skp2-targeting agent that warrants further clinical investigation.<\/p>\n

Article Reference:<\/strong> Shi-Bing Zhang, Ming Hong and Xiao-Yang Sun et al. Silybin has therapeutic efficacy against non-small cell lung cancer through targeting of Skp2.\u00a0Acta Materia Medica.\u00a0<\/em>Vol. 1(3):302-313. DOI: 10.15212\/AMM-2022-0011<\/p>\n

https:\/\/www.scienceopen.com\/hosted-document?doi=10.15212\/AMM-2022-0011<\/a><\/p>\n

Keywords:<\/strong> silybin, NSCLC, Skp2, p27, cell-cycle arrest<\/p>\n

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 <\/p>\n","protected":false},"excerpt":{"rendered":"

Announcing a new review article publication for Acta Materia Medica journal. Silybin (SB), a natural flavonoid isolated from\u00a0Silybum marianum, has been used to treat hepatic fibrosis in clinical settings and as a dietary supplement, because of its hepatoprotective potential. Numerous studies have shown that SB also exerts promising anticancer effects; however, the anticancer targets of […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2],"tags":[91,88,90,87,89],"class_list":["post-376","post","type-post","status-publish","format-standard","hentry","category-news-and-events","tag-cell-cycle-arrest","tag-nsclc","tag-p27","tag-silybin","tag-skp2"],"yoast_head":"\nSilybin has therapeutic efficacy against non-small cell lung cancer through targeting of Skp2 - AMM Journal<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/amm-journal.org\/index.php\/2022\/08\/04\/silybin-has-therapeutic-efficacy-against-non-small-cell-lung-cancer-through-targeting-of-skp2\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Silybin has therapeutic efficacy against non-small cell lung cancer through targeting of Skp2 - AMM Journal\" \/>\n<meta property=\"og:description\" content=\"Announcing a new review article publication for Acta Materia Medica journal. 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