{"id":309,"date":"2022-04-14T20:05:17","date_gmt":"2022-04-14T20:05:17","guid":{"rendered":"https:\/\/amm-journal.org\/?p=309"},"modified":"2022-04-14T20:06:11","modified_gmt":"2022-04-14T20:06:11","slug":"effects-of-b-carotene-on-glucose-metabolism-dysfunction-in-humans-and-type-2-diabetic-rats","status":"publish","type":"post","link":"https:\/\/amm-journal.org\/index.php\/2022\/04\/14\/effects-of-b-carotene-on-glucose-metabolism-dysfunction-in-humans-and-type-2-diabetic-rats\/","title":{"rendered":"Effects of B-carotene on glucose metabolism dysfunction in humans and type 2 diabetic rats"},"content":{"rendered":"
Announcing a new review article publication for Acta Materia Medica<\/em> journal. Type 2 diabetes mellitus (T2DM) is a common chronic disease that is strongly associated with cardiovascular risk. Long-term high blood glucose levels may induce cardiomyocyte apoptosis, cardiac dysfunction and suppress fetal cardiomyocyte proliferation. Recent epidemiological studies have shown a link between antioxidant carotenoids and T2DM, but a comprehensive longitudinal study of this association has not yet been conducted.<\/h5>\n

The authors of this article included participants with biological measurements for both serum cis-\u03b2-carotene and fasting glucose from NHANES (2001\u20132006). The participants were divided into quartiles according to serum cis-\u03b2-carotene levels and determined the association between these levels and glucose metabolism by using multivariable regression models adjusted for confounding factors. The mechanism through which \u03b2-carotene levels regulate plasma glucose levels was further investigated in vivo and in vitro. In addition, we performed a preliminary exploration of the effects of \u03b2-carotene on diabetic rats and primary cardiomyocytes.<\/p>\n

Higher cis-\u03b2-carotene (quartile 4) was associated with higher LDL-cholesterol levels but lower fasting blood glucose levels. However, T2DM rats subjected to \u03b2-carotene treatment showed diminished total triglycerides and LDL-cholesterol, and their \u03b2-carotene levels were associated with better cardiac function than that in the T2DM group (P<\/em><0.05). Moreover, \u03b2-carotene was found to be an important protective factor improving cardiac and mitochondrial function in diabetes. At non-cytotoxic doses, \u03b2-carotene clearly improved glucose uptake in insulin-resistant cells. Treatment with \u03b2-carotene increased GLUT4 and p-Akt expression, and attenuated the phosphorylation of IRS-1. Our data demonstrated that \u03b2-carotene improved cardiac mitochondria biogenesis in diabetes due to activation of PGC-1\u03b2.<\/p>\n

The results indicate that \u03b2-carotene can be used to treat metabolic disorders through inhibition of the insulin-resistance pathway in diabetes.<\/p>\n

Article Reference:<\/strong> Jianjun Wu, Yinan Zhou and Hanqing Hu et al. Effects of \u03b2-carotene on glucose metabolism dysfunction in humans and type 2 diabetic rats. Acta Materia Medica. Vol. 1(1):138-153. DOI: 10.15212\/AMM-2021-0009<\/p>\n

Keywords:<\/strong> \u03b2-carotene, diabetes, insulin resistance, AKT\/IRS, mitochondria<\/p>\n

Acta Materia Medica<\/em> welcomes the submission of research articles, review articles, databases, mini reviews, commentaries, editorials, short communications, case report articles and study protocols.<\/p>\n

Submission Process<\/strong><\/p>\n

Submissions to Acta Materia Medica<\/em> are made using ScholarOne, the online submission and peer review system. Registration and access are available at https:\/\/mc04.manuscriptcentral.com\/ammed<\/a><\/p>\n

Queries about the journal can be sent to editorialoffice@amm-journal.org.<\/p>\n

Please visit https:\/\/amm-journal.org\/<\/a> to learn more about the journal.<\/p>\n

Editorial Board:<\/strong> https:\/\/amm-journal.org\/index.php\/editorial-board\/<\/a><\/p>\n

There are no author submission or article processing fees.<\/p>\n

Follow Acta Materia Medica <\/em><\/strong>on Twitter https:\/\/twitter.com\/AMM_journal<\/a>\u00a0 ; Facebook<\/a> (https:\/\/www.facebook.com\/AMMjournal<\/a>)<\/p>\n

eISSN <\/strong>2737-7946<\/p>\n","protected":false},"excerpt":{"rendered":"

Announcing a new review article publication for Acta Materia Medica journal. Type 2 diabetes mellitus (T2DM) is a common chronic disease that is strongly associated with cardiovascular risk. Long-term high blood glucose levels may induce cardiomyocyte apoptosis, cardiac dysfunction and suppress fetal cardiomyocyte proliferation. Recent epidemiological studies have shown a link between antioxidant carotenoids and […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2],"tags":[50,48,49,18,47],"class_list":["post-309","post","type-post","status-publish","format-standard","hentry","category-news-and-events","tag-akt-irs","tag-diabetes","tag-insulin-resistance","tag-mitochondria","tag--carotene"],"yoast_head":"\nEffects of B-carotene on glucose metabolism dysfunction in humans and type 2 diabetic rats - AMM Journal<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/amm-journal.org\/index.php\/2022\/04\/14\/effects-of-b-carotene-on-glucose-metabolism-dysfunction-in-humans-and-type-2-diabetic-rats\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Effects of B-carotene on glucose metabolism dysfunction in humans and type 2 diabetic rats - AMM Journal\" \/>\n<meta property=\"og:description\" content=\"Announcing a new review article publication for Acta Materia Medica journal. Type 2 diabetes mellitus (T2DM) is a common chronic disease that is strongly associated with cardiovascular risk. Long-term high blood glucose levels may induce cardiomyocyte apoptosis, cardiac dysfunction and suppress fetal cardiomyocyte proliferation. Recent epidemiological studies have shown a link between antioxidant carotenoids and […]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/amm-journal.org\/index.php\/2022\/04\/14\/effects-of-b-carotene-on-glucose-metabolism-dysfunction-in-humans-and-type-2-diabetic-rats\/\" \/>\n<meta property=\"og:site_name\" content=\"AMM Journal\" \/>\n<meta property=\"article:published_time\" content=\"2022-04-14T20:05:17+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2022-04-14T20:06:11+00:00\" \/>\n<meta name=\"author\" content=\"Compuscript\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Compuscript\" \/>\n\t<meta name=\"twitter:label2\" content=\"Estimated reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/amm-journal.org\\\/index.php\\\/2022\\\/04\\\/14\\\/effects-of-b-carotene-on-glucose-metabolism-dysfunction-in-humans-and-type-2-diabetic-rats\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/amm-journal.org\\\/index.php\\\/2022\\\/04\\\/14\\\/effects-of-b-carotene-on-glucose-metabolism-dysfunction-in-humans-and-type-2-diabetic-rats\\\/\"},\"author\":{\"name\":\"Compuscript\",\"@id\":\"https:\\\/\\\/amm-journal.org\\\/#\\\/schema\\\/person\\\/0935dba5c919585e39f756ce09930a67\"},\"headline\":\"Effects of B-carotene on glucose metabolism dysfunction in humans and type 2 diabetic rats\",\"datePublished\":\"2022-04-14T20:05:17+00:00\",\"dateModified\":\"2022-04-14T20:06:11+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/amm-journal.org\\\/index.php\\\/2022\\\/04\\\/14\\\/effects-of-b-carotene-on-glucose-metabolism-dysfunction-in-humans-and-type-2-diabetic-rats\\\/\"},\"wordCount\":448,\"commentCount\":0,\"keywords\":[\"AKT\\\/IRS\",\"diabetes\",\"insulin resistance\",\"mitochondria\",\"\u03b2-carotene\"],\"articleSection\":[\"News and Events\"],\"inLanguage\":\"en-GB\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\\\/\\\/amm-journal.org\\\/index.php\\\/2022\\\/04\\\/14\\\/effects-of-b-carotene-on-glucose-metabolism-dysfunction-in-humans-and-type-2-diabetic-rats\\\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/amm-journal.org\\\/index.php\\\/2022\\\/04\\\/14\\\/effects-of-b-carotene-on-glucose-metabolism-dysfunction-in-humans-and-type-2-diabetic-rats\\\/\",\"url\":\"https:\\\/\\\/amm-journal.org\\\/index.php\\\/2022\\\/04\\\/14\\\/effects-of-b-carotene-on-glucose-metabolism-dysfunction-in-humans-and-type-2-diabetic-rats\\\/\",\"name\":\"Effects of B-carotene on glucose metabolism dysfunction in humans and type 2 diabetic rats - AMM Journal\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/amm-journal.org\\\/#website\"},\"datePublished\":\"2022-04-14T20:05:17+00:00\",\"dateModified\":\"2022-04-14T20:06:11+00:00\",\"author\":{\"@id\":\"https:\\\/\\\/amm-journal.org\\\/#\\\/schema\\\/person\\\/0935dba5c919585e39f756ce09930a67\"},\"breadcrumb\":{\"@id\":\"https:\\\/\\\/amm-journal.org\\\/index.php\\\/2022\\\/04\\\/14\\\/effects-of-b-carotene-on-glucose-metabolism-dysfunction-in-humans-and-type-2-diabetic-rats\\\/#breadcrumb\"},\"inLanguage\":\"en-GB\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/amm-journal.org\\\/index.php\\\/2022\\\/04\\\/14\\\/effects-of-b-carotene-on-glucose-metabolism-dysfunction-in-humans-and-type-2-diabetic-rats\\\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/amm-journal.org\\\/index.php\\\/2022\\\/04\\\/14\\\/effects-of-b-carotene-on-glucose-metabolism-dysfunction-in-humans-and-type-2-diabetic-rats\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/amm-journal.org\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Effects of B-carotene on glucose metabolism dysfunction in humans and type 2 diabetic rats\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/amm-journal.org\\\/#website\",\"url\":\"https:\\\/\\\/amm-journal.org\\\/\",\"name\":\"AMM Journal\",\"description\":\"\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/amm-journal.org\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-GB\"},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/amm-journal.org\\\/#\\\/schema\\\/person\\\/0935dba5c919585e39f756ce09930a67\",\"name\":\"Compuscript\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-GB\",\"@id\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/fb3d42af3c1b48f4d76adf5524c6c3447a369d2a7bcb666ef995240441912a6b?s=96&d=mm&r=g\",\"url\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/fb3d42af3c1b48f4d76adf5524c6c3447a369d2a7bcb666ef995240441912a6b?s=96&d=mm&r=g\",\"contentUrl\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/fb3d42af3c1b48f4d76adf5524c6c3447a369d2a7bcb666ef995240441912a6b?s=96&d=mm&r=g\",\"caption\":\"Compuscript\"},\"sameAs\":[\"https:\\\/\\\/amm-journal.org\"],\"url\":\"https:\\\/\\\/amm-journal.org\\\/index.php\\\/author\\\/ammjadmin\\\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Effects of B-carotene on glucose metabolism dysfunction in humans and type 2 diabetic rats - AMM Journal","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/amm-journal.org\/index.php\/2022\/04\/14\/effects-of-b-carotene-on-glucose-metabolism-dysfunction-in-humans-and-type-2-diabetic-rats\/","og_locale":"en_GB","og_type":"article","og_title":"Effects of B-carotene on glucose metabolism dysfunction in humans and type 2 diabetic rats - AMM Journal","og_description":"Announcing a new review article publication for Acta Materia Medica journal. Type 2 diabetes mellitus (T2DM) is a common chronic disease that is strongly associated with cardiovascular risk. Long-term high blood glucose levels may induce cardiomyocyte apoptosis, cardiac dysfunction and suppress fetal cardiomyocyte proliferation. Recent epidemiological studies have shown a link between antioxidant carotenoids and […]","og_url":"https:\/\/amm-journal.org\/index.php\/2022\/04\/14\/effects-of-b-carotene-on-glucose-metabolism-dysfunction-in-humans-and-type-2-diabetic-rats\/","og_site_name":"AMM Journal","article_published_time":"2022-04-14T20:05:17+00:00","article_modified_time":"2022-04-14T20:06:11+00:00","author":"Compuscript","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Compuscript","Estimated reading time":"2 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/amm-journal.org\/index.php\/2022\/04\/14\/effects-of-b-carotene-on-glucose-metabolism-dysfunction-in-humans-and-type-2-diabetic-rats\/#article","isPartOf":{"@id":"https:\/\/amm-journal.org\/index.php\/2022\/04\/14\/effects-of-b-carotene-on-glucose-metabolism-dysfunction-in-humans-and-type-2-diabetic-rats\/"},"author":{"name":"Compuscript","@id":"https:\/\/amm-journal.org\/#\/schema\/person\/0935dba5c919585e39f756ce09930a67"},"headline":"Effects of B-carotene on glucose metabolism dysfunction in humans and type 2 diabetic rats","datePublished":"2022-04-14T20:05:17+00:00","dateModified":"2022-04-14T20:06:11+00:00","mainEntityOfPage":{"@id":"https:\/\/amm-journal.org\/index.php\/2022\/04\/14\/effects-of-b-carotene-on-glucose-metabolism-dysfunction-in-humans-and-type-2-diabetic-rats\/"},"wordCount":448,"commentCount":0,"keywords":["AKT\/IRS","diabetes","insulin resistance","mitochondria","\u03b2-carotene"],"articleSection":["News and Events"],"inLanguage":"en-GB","potentialAction":[{"@type":"CommentAction","name":"Comment","target":["https:\/\/amm-journal.org\/index.php\/2022\/04\/14\/effects-of-b-carotene-on-glucose-metabolism-dysfunction-in-humans-and-type-2-diabetic-rats\/#respond"]}]},{"@type":"WebPage","@id":"https:\/\/amm-journal.org\/index.php\/2022\/04\/14\/effects-of-b-carotene-on-glucose-metabolism-dysfunction-in-humans-and-type-2-diabetic-rats\/","url":"https:\/\/amm-journal.org\/index.php\/2022\/04\/14\/effects-of-b-carotene-on-glucose-metabolism-dysfunction-in-humans-and-type-2-diabetic-rats\/","name":"Effects of B-carotene on glucose metabolism dysfunction in humans and type 2 diabetic rats - AMM Journal","isPartOf":{"@id":"https:\/\/amm-journal.org\/#website"},"datePublished":"2022-04-14T20:05:17+00:00","dateModified":"2022-04-14T20:06:11+00:00","author":{"@id":"https:\/\/amm-journal.org\/#\/schema\/person\/0935dba5c919585e39f756ce09930a67"},"breadcrumb":{"@id":"https:\/\/amm-journal.org\/index.php\/2022\/04\/14\/effects-of-b-carotene-on-glucose-metabolism-dysfunction-in-humans-and-type-2-diabetic-rats\/#breadcrumb"},"inLanguage":"en-GB","potentialAction":[{"@type":"ReadAction","target":["https:\/\/amm-journal.org\/index.php\/2022\/04\/14\/effects-of-b-carotene-on-glucose-metabolism-dysfunction-in-humans-and-type-2-diabetic-rats\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/amm-journal.org\/index.php\/2022\/04\/14\/effects-of-b-carotene-on-glucose-metabolism-dysfunction-in-humans-and-type-2-diabetic-rats\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/amm-journal.org\/"},{"@type":"ListItem","position":2,"name":"Effects of B-carotene on glucose metabolism dysfunction in humans and type 2 diabetic rats"}]},{"@type":"WebSite","@id":"https:\/\/amm-journal.org\/#website","url":"https:\/\/amm-journal.org\/","name":"AMM Journal","description":"","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/amm-journal.org\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-GB"},{"@type":"Person","@id":"https:\/\/amm-journal.org\/#\/schema\/person\/0935dba5c919585e39f756ce09930a67","name":"Compuscript","image":{"@type":"ImageObject","inLanguage":"en-GB","@id":"https:\/\/secure.gravatar.com\/avatar\/fb3d42af3c1b48f4d76adf5524c6c3447a369d2a7bcb666ef995240441912a6b?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/fb3d42af3c1b48f4d76adf5524c6c3447a369d2a7bcb666ef995240441912a6b?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/fb3d42af3c1b48f4d76adf5524c6c3447a369d2a7bcb666ef995240441912a6b?s=96&d=mm&r=g","caption":"Compuscript"},"sameAs":["https:\/\/amm-journal.org"],"url":"https:\/\/amm-journal.org\/index.php\/author\/ammjadmin\/"}]}},"_links":{"self":[{"href":"https:\/\/amm-journal.org\/index.php\/wp-json\/wp\/v2\/posts\/309","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/amm-journal.org\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/amm-journal.org\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/amm-journal.org\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/amm-journal.org\/index.php\/wp-json\/wp\/v2\/comments?post=309"}],"version-history":[{"count":3,"href":"https:\/\/amm-journal.org\/index.php\/wp-json\/wp\/v2\/posts\/309\/revisions"}],"predecessor-version":[{"id":312,"href":"https:\/\/amm-journal.org\/index.php\/wp-json\/wp\/v2\/posts\/309\/revisions\/312"}],"wp:attachment":[{"href":"https:\/\/amm-journal.org\/index.php\/wp-json\/wp\/v2\/media?parent=309"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/amm-journal.org\/index.php\/wp-json\/wp\/v2\/categories?post=309"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/amm-journal.org\/index.php\/wp-json\/wp\/v2\/tags?post=309"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}