{"id":261,"date":"2022-01-31T14:44:40","date_gmt":"2022-01-31T14:44:40","guid":{"rendered":"https:\/\/amm-journal.org\/?p=261"},"modified":"2022-01-31T14:44:40","modified_gmt":"2022-01-31T14:44:40","slug":"regulation-of-neuronal-autophagy-and-cell-survival-by-mcl1-in-alzheimers-disease","status":"publish","type":"post","link":"https:\/\/amm-journal.org\/index.php\/2022\/01\/31\/regulation-of-neuronal-autophagy-and-cell-survival-by-mcl1-in-alzheimers-disease\/","title":{"rendered":"Regulation of Neuronal Autophagy and Cell Survival by MCL1 in Alzheimer\u2019s Disease"},"content":{"rendered":"<p>Announcing a new review article publication for<em> Acta Materia Medica<\/em> journal. In this review article, the authors discuss the emerging neuroprotective function of MCL1 and how dysregulation of MCL1 signaling is involved in the pathogenesis of AD. Because members of the pro-survival BCL2 family proteins are promising targets of pharmacological intervention with BH3 mimetic drugs, the promise of MCL1-targeting therapy in AD is also discussed.<\/p>\n<p>Maintaining neuronal integrity and function requires precise mechanisms controlling organelle and protein quality. Alzheimer\u2019s disease (AD) is also characterized by functional defects in the clearance and recycling of intracellular components. In fact, neuronal homeostasis involves autophagy, mitophagy, apoptosis, and compromised activity in these cellular processes may cause pathological phenotypes of AD. Therefore, mitophagy is a critical mitochondrial quality-control system, and impaired mitophagy is a hallmark of AD. Myeloid cell leukemia 1 (MCL1), a member of the pro-survival B-cell lymphoma protein 2 (BCL2) family, is a mitochondrially targeted protein that contributes to maintaining mitochondrial integrity. Mcl1-knockout mice display peri-implantation lethality.<\/p>\n<p>Studies on conditional Mcl1-knockout mice have demonstrated that MCL1 plays a central role in neurogenesis and neuronal survival during brain development. Accumulating evidence indicates the critical role of MCL1 as a regulator of neuronal autophagy, mitophagy, and survival.<\/p>\n<p>DOI <a href=\"https:\/\/www.scienceopen.com\/hosted-document?doi=10.15212\/AMM-2021-0002\">10.15212\/AMM-2021-0002<\/a><\/p>\n<p><strong>Article Reference:<\/strong> Abdol-Hossein Rezaeian, Wenyi Wei and Hiroyuki Inuzuka. Regulation of neuronal autophagy and cell survival by MCL1 in Alzheimer\u2019s disease.\u00a0<em>Acta Materia Medica.\u00a0<\/em>Vol. 1(1). DOI: 10.15212\/AMM-2021-0002<\/p>\n<p><strong>Keywords:<\/strong> Alzheimer\u2019s disease, mitochondria, autophagy, mitophagy, apoptosis, MCL1, BH3 mimetics<\/p>\n<p><em>Acta Materia Medica<\/em> welcomes the submission of research articles, review articles, databases, mini reviews, commentaries, editorials, short communications, case report articles and study protocols.<\/p>\n<p><strong>Submission Process<\/strong><\/p>\n<p>Submissions <em>to Acta Materia Medica<\/em> are made using ScholarOne, the online submission and peer review system. Registration and access are available at <a href=\"https:\/\/mc04.manuscriptcentral.com\/ammed\">https:\/\/mc04.manuscriptcentral.com\/ammed<\/a><\/p>\n<p>Queries about the journal can be sent to editorialoffice@amm-journal.org.<\/p>\n<p>Please visit <a href=\"https:\/\/amm-journal.org\/\">https:\/\/amm-journal.org\/<\/a> to learn more about the journal.<\/p>\n<p><strong>Editorial Board:<\/strong> <a href=\"https:\/\/amm-journal.org\/index.php\/editorial-board\/\">https:\/\/amm-journal.org\/index.php\/editorial-board\/<\/a><\/p>\n<p>There are no author submission or article processing fees.<\/p>\n<p>Follow <strong><em>Acta Materia Medica <\/em><\/strong>on Twitter <a href=\"https:\/\/twitter.com\/AMM_journal\">https:\/\/twitter.com\/AMM_journal<\/a>\u00a0 ; <a href=\"https:\/\/www.facebook.com\/Zoonoses-Journal-100462755574114\">Facebook<\/a> (<a href=\"https:\/\/www.facebook.com\/AMMjournal\">https:\/\/www.facebook.com\/AMMjournal<\/a>)<\/p>\n<p><strong>eISSN <\/strong>2737-7946<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Announcing a new review article publication for Acta Materia Medica journal. In this review article, the authors discuss the emerging neuroprotective function of MCL1 and how dysregulation of MCL1 signaling is involved in the pathogenesis of AD. Because members of the pro-survival BCL2 family proteins are promising targets of pharmacological intervention with BH3 mimetic drugs, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2],"tags":[17,20,16,22,21,18,19],"class_list":["post-261","post","type-post","status-publish","format-standard","hentry","category-news-and-events","tag-alzheimers-disease","tag-apoptosis","tag-autophagy","tag-bh3-mimetics","tag-mcl1","tag-mitochondria","tag-mitophagy"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Regulation of Neuronal Autophagy and Cell Survival by MCL1 in Alzheimer\u2019s Disease - AMM Journal<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/amm-journal.org\/index.php\/2022\/01\/31\/regulation-of-neuronal-autophagy-and-cell-survival-by-mcl1-in-alzheimers-disease\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Regulation of Neuronal Autophagy and Cell Survival by MCL1 in Alzheimer\u2019s Disease - AMM Journal\" \/>\n<meta property=\"og:description\" content=\"Announcing a new review article publication for Acta Materia Medica journal. In this review article, the authors discuss the emerging neuroprotective function of MCL1 and how dysregulation of MCL1 signaling is involved in the pathogenesis of AD. 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