{"id":1943,"date":"2026-05-26T13:00:10","date_gmt":"2026-05-26T13:00:10","guid":{"rendered":"https:\/\/amm-journal.org\/?p=1943"},"modified":"2026-05-28T10:05:18","modified_gmt":"2026-05-28T10:05:18","slug":"rad51-cancer-progression-precision-oncology","status":"publish","type":"post","link":"https:\/\/amm-journal.org\/index.php\/2026\/05\/26\/rad51-cancer-progression-precision-oncology\/","title":{"rendered":"RAD51 recombinase: biology, regulation, and therapeutic targeting"},"content":{"rendered":"

Announcing a new publication for Acta Materia Medica<\/em> journal. Accurate repair of DNA double-strand breaks (DSBs) is essential for maintaining genomic integrity. RAD51, the core recombinase in homologous recombination, plays central roles in repairing DNA damage and protecting stalled replication forks. In normal cells, RAD51 helps maintain genomic integrity; however, in cancer, its overexpression often supports replication-stress tolerance, as well as resistance to chemotherapy, radiotherapy, and PARP inhibitors. RAD51 is tightly controlled at multiple levels, including transcriptional, post-transcriptional, and post-translational regulation, which together shape its activity in different biological contexts. This review summarizes the structural features of RAD51, its regulatory networks, and its roles in human disease, with particular emphasis on cancer progression and treatment resistance. Currently available RAD51 inhibitors, their mechanisms of action, and the main challenges that still limit clinical translation are discussed. Together, current findings indicate that RAD51 is a key genome maintenance factor and a promising therapeutic target in precision oncology.<\/p>\n

Read full open access article: https:\/\/www.scienceopen.com\/hosted-document?doi=10.15212\/AMM-2026-0001<\/a><\/p>\n

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Zhigao Chen, Yige Ding and Lin Yang. RAD51 recombinase: biology, regulation, and therapeutic targeting.\u00a0Acta Materia Medica.\u00a0<\/em>2026. Vol. 5(1):144-158. DOI: 10.15212\/AMM-2026-0001<\/p>\n","protected":false},"excerpt":{"rendered":"

Announcing a new publication for Acta Materia Medica journal. Accurate repair of DNA double-strand breaks (DSBs) is essential for maintaining genomic integrity. RAD51, the core recombinase in homologous recombination, plays central roles in repairing DNA damage and protecting stalled replication forks. In normal cells, RAD51 helps maintain genomic integrity; however, in cancer, its overexpression often […]<\/p>\n","protected":false},"author":6,"featured_media":1945,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2],"tags":[577,578,575,576],"class_list":["post-1943","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news-and-events","tag-cancer-progression","tag-precision-oncology","tag-rad51","tag-regulatory-networks"],"yoast_head":"\nRAD51 recombinase: biology, regulation, and therapeutic targeting - AMM Journal<\/title>\n<meta name=\"description\" content=\"This review provides a comprehensive overview of RAD51, detailing its structural features, regulatory networks, and roles in human disease\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/amm-journal.org\/index.php\/2026\/05\/26\/rad51-cancer-progression-precision-oncology\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"RAD51 recombinase: biology, regulation, and therapeutic targeting - 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