{"id":1920,"date":"2026-04-02T07:18:30","date_gmt":"2026-04-02T07:18:30","guid":{"rendered":"https:\/\/amm-journal.org\/?p=1920"},"modified":"2026-04-02T07:18:30","modified_gmt":"2026-04-02T07:18:30","slug":"psoriasis-euphorbia-humifusa-willd-extract-avicularin-inflammation-keratinocyte-proliferation","status":"publish","type":"post","link":"https:\/\/amm-journal.org\/index.php\/2026\/04\/02\/psoriasis-euphorbia-humifusa-willd-extract-avicularin-inflammation-keratinocyte-proliferation\/","title":{"rendered":"Network pharmacology-guided discovery of avicularin from Euphorbia humifusa Willd. targeting IL-17 signaling in psoriasis"},"content":{"rendered":"

Announcing a new publication for Acta Materia Medica<\/em><\/a> journal. \u00a0Despite therapeutic advances, long-term psoriasis management remains challenged by cost, immunogenicity, and administration barriers. Although the anti-inflammatory properties of avicularin (AL) are recognized, its direct targeting of IL-17RA and its therapeutic efficacy in psoriasis remain unreported. The authors of this article established the efficacy of\u00a0Euphorbia humifusa<\/em>\u00a0Willd. (EH) in a psoriasis mouse model, then used an integrated strategy combining network pharmacology, RNA-seq, and surface plasmon resonance-mass spectrometry (SPR-MS) to assess its pharmacodynamic material basis. This systematic approach identified the IL-17 pathway as the primary mechanism, and IL-6, CXCL10, and IL-17RA as key targets. On the basis of these key targets, SPR-MS screened seven candidate compounds from EH, among which AL was confirmed as a key IL-17RA-targeting bioactive compound.<\/p>\n

Subsequent validation demonstrated that AL dose-dependently ameliorated psoriatic lesions and downregulated key IL-17 pathway effectors, including IL-17RA, IL-6, and CXCL10 (p<\/em>\u00a0< 0.05). Direct binding between AL and IL-17RA was subsequently confirmed through bio-layer interferometry, SPR-MS re-screening, and molecular docking. These findings not only establish AL as a promising oral IL-17RA-targeted agent but also delineate a robust strategy that may aid in the systematic discovery of active natural compounds.<\/p>\n

Read More:\u00a0https:\/\/www.scienceopen.com\/hosted-document?doi=10.15212\/AMM-2025-0058<\/a><\/p>\n

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Qianqian Zhou, Zhe Wang and Yuanxiang Wang et al. Network pharmacology-guided discovery of avicularin from Euphorbia humifusa Willd. targeting IL-17 signaling in psoriasis.\u00a0Acta Materia Medica.\u00a0<\/em>2026. Vol. 5(1):88-112. DOI: 10.15212\/AMM-2025-0058<\/p>\n","protected":false},"excerpt":{"rendered":"

Announcing a new publication for Acta Materia Medica journal. \u00a0Despite therapeutic advances, long-term psoriasis management remains challenged by cost, immunogenicity, and administration barriers. Although the anti-inflammatory properties of avicularin (AL) are recognized, its direct targeting of IL-17RA and its therapeutic efficacy in psoriasis remain unreported. The authors of this article established the efficacy of\u00a0Euphorbia humifusa\u00a0Willd. […]<\/p>\n","protected":false},"author":5,"featured_media":1921,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2],"tags":[567,569,167,568,570,464],"class_list":["post-1920","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news-and-events","tag-avicularin","tag-il-17","tag-inflammation","tag-keratinocyte","tag-natural-product-research","tag-psoriasis"],"yoast_head":"\nNetwork pharmacology-guided discovery of avicularin from Euphorbia humifusa Willd. targeting IL-17 signaling in psoriasis<\/title>\n<meta name=\"description\" content=\"This research demonstrates that Euphorbia humifusa Willd. extract and avicularin inhibit inflammation and abnormal keratinocyte proliferation in psoriasis.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" 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