{"id":1902,"date":"2026-02-23T11:33:03","date_gmt":"2026-02-23T11:33:03","guid":{"rendered":"https:\/\/amm-journal.org\/?p=1902"},"modified":"2026-02-23T11:33:03","modified_gmt":"2026-02-23T11:33:03","slug":"osteoarthritis-rheumatoid-arthritis-diacerein","status":"publish","type":"post","link":"https:\/\/amm-journal.org\/index.php\/2026\/02\/23\/osteoarthritis-rheumatoid-arthritis-diacerein\/","title":{"rendered":"From osteoarthritis to rheumatoid arthritis: re-exploring the molecular pathways and therapeutic potential of diacerein"},"content":{"rendered":"

Announcing a new publication for Acta Materia Medica<\/em> journal<\/a>. Diacerein, an anthraquinone derivative, is emerging as a promising disease-modifying agent in rheumatoid arthritis (RA), because of its potent anti-inflammatory and chondroprotective actions. Unlike nonsteroidal anti-inflammatory drugs, which primarily inhibit cyclooxygenase enzymes, diacerein suppresses interleukin-1\u03b2, a central mediator of synovial inflammation and cartilage degradation. It also modulates tumor necrosis factor-alpha and matrix metalloproteinases, thereby alleviating pain, decreasing inflammation, and preserving joint structure.<\/p>\n

This review of clinical and preclinical studies highlights the therapeutic potential of diacerein in RA management, focusing on its molecular mechanisms, clinical outcomes, and combination strategies with disease-modifying antirheumatic drugs (DMARDs) or biologics. Recent advances in drug delivery, including nanoparticle-based and sustained-release formulations, have further enhanced its bioavailability and efficacy. Diacerein effectively decreases joint swelling and stiffness, while demonstrating a superior gastrointestinal safety profile to nonsteroidal anti-inflammatory drugs. However, its slow onset of action and moderate efficacy as a monotherapy limit its standalone use.<\/p>\n

Combination therapy with DMARDs or biologics appears to potentiate its therapeutic benefits. Overall, diacerein is a valuable adjunctive agent in RA treatment. Further studies are warranted to optimize dosing regimens and delivery systems to improve clinical outcomes.<\/p>\n

Read More:\u00a0https:\/\/www.scienceopen.com\/hosted-document?doi=10.15212\/AMM-2025-0076<\/a><\/p>\n

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eISSN <\/strong>2737-7946<\/p>\n

Subarnarekha Maitra, Sreemoy Kanti Das and Dibya Sinha et al. From osteoarthritis to rheumatoid arthritis: re-exploring the molecular pathways and therapeutic potential of diacerein.\u00a0Acta Materia Medica.\u00a0<\/em>2026. Vol. 5(1):55-69. DOI: 10.15212\/AMM-2025-0076<\/p>\n","protected":false},"excerpt":{"rendered":"

Announcing a new publication for Acta Materia Medica journal. Diacerein, an anthraquinone derivative, is emerging as a promising disease-modifying agent in rheumatoid arthritis (RA), because of its potent anti-inflammatory and chondroprotective actions. Unlike nonsteroidal anti-inflammatory drugs, which primarily inhibit cyclooxygenase enzymes, diacerein suppresses interleukin-1\u03b2, a central mediator of synovial inflammation and cartilage degradation. It also […]<\/p>\n","protected":false},"author":5,"featured_media":1903,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2],"tags":[130,554,552,553,555,166],"class_list":["post-1902","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news-and-events","tag-anti-inflammatory","tag-chondroprotection","tag-diacerein","tag-dmards","tag-osteoarthritis","tag-rheumatoid-arthritis"],"yoast_head":"\nFrom osteoarthritis to rheumatoid arthritis: re-exploring the molecular pathways and therapeutic potential of diacerein<\/title>\n<meta name=\"description\" content=\"Diacerein reduces inflammation and cartilage damage in rheumatoid arthritis, with improved delivery and combination therapy enhancing its treatment potential.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" 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