{"id":1732,"date":"2025-11-03T12:38:08","date_gmt":"2025-11-03T12:38:08","guid":{"rendered":"https:\/\/amm-journal.org\/?p=1732"},"modified":"2025-11-03T12:38:08","modified_gmt":"2025-11-03T12:38:08","slug":"r18-inhibitor-dengue-virus-envelope-protein","status":"publish","type":"post","link":"https:\/\/amm-journal.org\/index.php\/2025\/11\/03\/r18-inhibitor-dengue-virus-envelope-protein\/","title":{"rendered":"Discovery of vina-ginsenoside R18 as a novel dual-target inhibitor of dengue virus envelope protein and RNA-dependent RNA polymerase"},"content":{"rendered":"

Announcing a new publication for Acta Materia Medica<\/em><\/a> journal. Dengue virus (DENV) poses a serious health threat globally for which specific antivirals are not available.<\/p>\n

Envelope (E) protein and RNA-dependent RNA polymerase (RdRp) from DENV represent the most critical targets for the development of antivirals that inhibit viral adsorption for entry and genome replication, respectively; no dual inhibitors targeting E\/RdRp have been reported to date. Vina-ginsenoside R18 (R18), a triterpenoid saponin isolated from\u00a0Panax notoginseng<\/em>, was shown to target E protein domain III to inhibit binding of E protein to integrin beta3, thus preventing viral adsorption to the host surface receptor. R18 selectively targets RdRp protein and induces a conformational change, leading to a decrease in enzyme activity. Consequently, R18 represses DENV infection by acting at viral binding, entry, and replication stages, and attenuates the pathologic symptoms of DENV-infected ICR suckling and AG129 mice.<\/p>\n

These results show R18 to be a novel dual E\/RdRp inhibitor that can serve a potential agent against DENV infection.<\/p>\n

Read More:\u00a0https:\/\/www.scienceopen.com\/hosted-document?doi=10.15212\/AMM-2024-0094<\/a><\/p>\n

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eISSN <\/strong>2737-7946<\/p>\n

Xuemei He, Yuanru Zheng and Lifang Zou et al. Discovery of vina-ginsenoside R18 as a novel dual-target inhibitor of dengue virus envelope protein and RNA-dependent RNA polymerase.\u00a0Acta Materia Medica.\u00a0<\/em>2025. Vol. 4(4):612-629. DOI: 10.15212\/AMM-2024-0094<\/p>\n","protected":false},"excerpt":{"rendered":"

Announcing a new publication for Acta Materia Medica journal. Dengue virus (DENV) poses a serious health threat globally for which specific antivirals are not available. Envelope (E) protein and RNA-dependent RNA polymerase (RdRp) from DENV represent the most critical targets for the development of antivirals that inhibit viral adsorption for entry and genome replication, respectively; […]<\/p>\n","protected":false},"author":5,"featured_media":1733,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2],"tags":[537,535,534,533,536],"class_list":["post-1732","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news-and-events","tag-dengue","tag-panaxnotoginseng","tag-saponin","tag-triterpenoid","tag-viralentry"],"yoast_head":"\nDiscovery of vina-ginsenoside R18 as a novel dual-target inhibitor of dengue virus envelope protein and RNA-dependent RNA polymerase<\/title>\n<meta name=\"description\" content=\"Vina-ginsenoside R18, acts as the first dual inhibitor of dengue virus E protein and RdRp, blocking viral entry and replication 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